A facile synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines

被引：11

作者：

Hu, Min ^{[1
]}

Guzzo, Peter R. ^{[1
]}

Zha, Congxiang ^{[1
]}

Nacro, Kassoum ^{[1
]}

Yang, Yuh-Lin ^{[1
]}

Hassler, Carla ^{[1
]}

Liu, Shuang ^{[1
]}

机构：

[1] AMRI, Albany, NY 12212 USA

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 07期

关键词：

Tetrahydroisoquinoline; THIQ; Arylation; Dihydroisoquinolinone; Palladium; CATALYZED ALPHA-ARYLATION; KETONES;

D O I：

10.1016/j.tetlet.2011.12.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and versatile palladium catalyzed alpha-arylation between dihydroisoquinolinones and various aryl halides is described. Combined with borane reduction, it provides a convenient way to prepare 4-aryl-1,2,3,4-tetrahydroisoquinolines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：846 / 848

页数：3

共 12 条

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