Effects of androgen receptor polyglutamine tract expansion on proliferation of NG108-15 cells

被引：8

作者：

Nakajima, H

Kimura, F

Nakagawa, T

Ikemoto, T

Furutama, D

Shinoda, K

Kato, S

Shimizu, A

Ohsawa, N

机构：

[1] OSAKA MED COLL,DEPT CLIN PATHOL,TAKATSUKI,OSAKA 56911,JAPAN

[2] OSAKA MED COLL,DEPT CENT LAB,TAKATSUKI,OSAKA 56911,JAPAN

[3] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 222卷 / 02期

关键词：

X-linked spinal and bulbar muscular atrophy; androgen receptor gene; polyglutamine tracts; CAG repeat; NG108-15; cells; cell proliferation; cell cycle;

D O I：

10.1016/S0304-3940(97)13348-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expansion of the polyglutamine tracts in the androgen receptor (AR) has been recognized as a cause of X-linked spinal and bulbar muscular atrophy (SBMA). In the present study, NG108-15 cells were stably transfected with expression vectors coding for either the wild type (WI) AR gene (GAG repeat number=22) or a mutated (MT) AR gene (GAG repeat number=52). Cells proliferation and cell cycle parameters were evaluated for NG108-15-WT and NG108-15-MT cells in the presence or absence of androgen. NG108-15-WT cells demonstrated an androgen-dependent increase in cell number, while NG108-15-MT cells did not. Our results demonstrate that expansion of polyglutamine tracts in the AR may affect the proliferation and differentiation of nerve cells. (C) 1997 Elsevier Science Ireland Ltd.

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收藏

页码：83 / 86

页数：4

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