Acute Exercise-Induced Circulating Haematopoietic Stem and Progenitor Cells in Cardiac Patients - A Case Series

被引:2
作者
Kroepfl, J. M. [1 ,2 ]
Tschakert, G. [3 ]
Stelzer, I [4 ]
Pekovits, K. [5 ]
Zelzer, S. [6 ]
Dohr, G. [7 ]
Holasek, S. [8 ]
Stojakovic, T. [6 ]
Scharnagl, H. [6 ]
Spengler, C. M. [1 ]
Hofmann, P. [3 ]
机构
[1] Swiss Fed Inst Technol, Inst Human Movement Sci & Sport, Exercise Physiol Lab, Winterthurerstr 190, CH-18057 Zurich, Switzerland
[2] Med Univ Graz, Inst Biophys, Graz, Austria
[3] Karl Franzens Univ Graz, Inst Sports Sci, Exercise Physiol & Training Res Grp, Graz, Austria
[4] LKH Hochsteiermark, Inst Med & Chem Lab Diagnost, Leoben, Austria
[5] Med Univ Graz, Dept Ophthalmol, Graz, Austria
[6] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria
[7] Med Univ Graz, Inst Cell Biol Histol & Embryol, Graz, Austria
[8] Med Univ Graz, Inst Pathophysiol & Immunol, Graz, Austria
关键词
HPC mobilisation; Cardiac rehabilitation; beta-adrenoreceptor antagonist; MYOCARDIAL-INFARCTION; BONE-MARROW; REHABILITATION; REGENERATION;
D O I
10.1016/j.hlc.2018.05.095
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Exercise-induced circulating haematopoietic stem and progenitor cell (HPC) number has been discussed in the context of regeneration in heart disease patients. Objective The aim of this pilot study was to compare the effect of different exercise protocols usually applied in cardiac rehabilitation on the number of acute, exercise-induced HPCs, related to potential mediators, e.g. biomarkers of sympathetic and oxidative stress, and inflammation. Methods This is a case series comprising seven patients suffering from coronary heart disease (CHD) undertaken at the Center for Ambulant Cardiac Rehabilitation. Patients (n = 6) performed two exercise modes (constant-load, CLE; high-intensity interval, HIIE) in randomised order. Venous blood was drawn before and immediately after each test to assess CD34+/CD45+ HPC number by flow cytometry and biomarkers in blood plasma. The primary outcome was the change in HPC number, the secondary outcomes were changes in sympathetic/oxidative stress and markers of inflammation. Results Both exercise modes resulted in a non-significant increase in HPC number after exercise, even when the results of both tests were combined. Overall, free norepinephrine increased significantly and was positively related to exercise-induced HPC number (r = 0.70, p < 0.05). Markers of sympathetic activation (fNE), oxidative stress (myeloperoxidase) and inflammation (interleukin-6) significantly increased after CLE and HIIE with no difference between tests. Conclusions Interestingly, acute CLE and HIIE did not stimulate significant HPC mobilisation in CHD, although both exercise modes elevated circulating concentrations of sympathetic activation. Haematopoietic stem and progenitor cell mobilisation could be blunted due to disease-related bone-marrow exhaustion.
引用
收藏
页码:E54 / E58
页数:5
相关论文
共 15 条
  • [1] Vigorous exercise mobilizes CD34+hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor
    Agha, Nadia H.
    Baker, Forrest L.
    Kunz, Hawley E.
    Graff, Rachel
    Azadan, Rod
    Dolan, Chad
    Laughlin, Mitzi S.
    Hosing, Chitra
    Markofski, Melissa M.
    Bond, Richard A.
    Bollard, Catherine M.
    Simpson, Richard J.
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2018, 68 : 66 - 75
  • [2] Exercise and Hematopoietic Stem and Progenitor Cells: Protection, Quantity, and Function
    De Lisio, Michael
    Parise, Gianni
    [J]. EXERCISE AND SPORT SCIENCES REVIEWS, 2013, 41 (02): : 116 - 122
  • [3] Cardiac Regeneration and Cellular Therapy: Is there a Benefit of Exercise?
    Figueiredo, P. A.
    Coriolano, H. -J. Appell
    Duarte, J. A.
    [J]. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2014, 35 (03) : 181 - 190
  • [4] Comparison of Different Forms of Exercise Training in Patients With Cardiac Disease: Where Does High-Intensity Interval Training Fit?
    Gayda, Mathieu
    Ribeiro, Paula A. B.
    Juneau, Martin
    Nigam, Anil
    [J]. CANADIAN JOURNAL OF CARDIOLOGY, 2016, 32 (04) : 485 - 494
  • [5] The Beneficial Effects of Cardiac Rehabilitation on the Function and Levels of Endothelial Progenitor Cells
    Guo, Yuan
    Ledesma, Robert Andre
    Peng, Ran
    Liu, Qiong
    Xu, Danyan
    [J]. HEART LUNG AND CIRCULATION, 2017, 26 (01) : 10 - 17
  • [6] Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure
    Kissel, Christine K.
    Lehmann, Ralf
    Assmus, Birgit
    Aicher, Alexandra
    Honold, Joerg
    Fischer-Rasokat, Ulrich
    Heeschen, Christopher
    Spyridopoulos, Ioakim
    Dimmeler, Stefanie
    Zeiher, Andreas M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (24) : 2341 - 2349
  • [7] Exercise-Induced Norepinephrine Decreases Circulating Hematopoietic Stem and Progenitor Cell Colony-Forming Capacity
    Kroepfl, Julia M.
    Stelzer, Ingeborg
    Mangge, Harald
    Pekovits, Karin
    Fuchs, Robert
    Allard, Nathalie
    Schinagl, Lukas
    Hofmann, Peter
    Dohr, Gottfried
    Wallner-Liebmann, Sandra
    Domej, Wolfgang
    Mueller, Wolfram
    [J]. PLOS ONE, 2014, 9 (09):
  • [8] Exercise Increases the Frequency of Circulating Hematopoietic Progenitor Cells, But Reduces Hematopoietic Colony-Forming Capacity
    Kroepfl, Julia Maria
    Pekovits, Karin
    Stelzer, Ingeborg
    Fuchs, Robert
    Zelzer, Sieglinde
    Hofmann, Peter
    Sedlmayr, Peter
    Dohr, Gottfried
    Wallner-Liebmann, Sandra
    Domej, Wolfgang
    Mueller, Wolfram
    [J]. STEM CELLS AND DEVELOPMENT, 2012, 21 (16) : 2915 - 2925
  • [9] Myocardial infarction does not affect circulating haematopoietic stem and progenitor cell self-renewal ability in a rat model
    Kropfl, J. M.
    Spengler, C. M.
    Frobert, A.
    Ajalbert, G.
    Giraud, M. N.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2018, 103 (01) : 1 - 8
  • [10] Apoptosis of T-Cell Subsets after Acute High-Intensity Interval Exercise
    Krueger, Karsten
    Alack, Katharina
    Ringseis, Robert
    Mink, Lena
    Pfeifer, Elisabeth
    Schinle, Matthias
    Gindler, Katharina
    Kimmelmann, Lena
    Walscheid, Ruediger
    Muders, Kerstin
    Frech, Torsten
    Eder, Klaus
    Mooren, Frank-Christoph
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2016, 48 (10) : 2021 - 2029