The role of high-conductance calcium-activated potassium channel in headache and migraine pathophysiology

被引：11
作者：
Al-Karagholi, Mohammad Al-Mahdi [1 ]
Hakbilen, Cemile Ceren [1 ]
Ashina, Messoud [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Rigshosp Glostrup, Danish Headache Ctr,Dept Neurol, Copenhagen, Denmark
来源：
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2022年 / 131卷 / 05期
关键词：
human; ion channels as drug targets; migraine; pain; pain models; potassium channels; BKCA CHANNELS; CEPHALIC VASODILATION; ATTACKS; PAIN; GLIBENCLAMIDE; CILOSTAZOL; INHIBITOR; ARTERIES; MODELS; OPENER;
D O I：
10.1111/bcpt.13787
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Migraine is a common, neurovascular headache disorder with a complex molecular interplay. The involvement of ion channels in the pathogenesis of migraine gathered considerable attention with the findings that different ion channels subfamilies are expressed in trigeminovascular system, the physiological substrate of migraine pain, and several ion channel openers investigated in clinical trials with diverse primary endpoints caused headache as a frequent side effect. High-conductance (big) calcium-activated potassium (BKCa) channel is expressed in the cranial arteries and the trigeminal pain pathway. Recent clinical research revealed that infusion of BKCa channel opener MaxiPost caused vasodilation, headache and migraine attack. Thus, BKCa channel is involved in pathophysiological mechanisms underlying headache and migraine, and targeting BKCa channel presents a new potential strategy for migraine treatment.
引用
收藏
页码：347 / 354
页数：8
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