The JAK2V617F mutation is acquired secondary to the predisposing alteration in familial polycythaemia vera

被引:44
作者
Cario, H [1 ]
Goerttler, PS
Steimle, C
Levine, RL
Pahl, HL
机构
[1] Univ Hosp Ulm, Dept Paediat, Ulm, Germany
[2] Univ Hosp Freiburg, Dept Expt Anaesthesiol, Freiburg, Germany
[3] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp, Boston, MA USA
关键词
myeloproliferative disorders;
D O I
10.1111/j.1365-2141.2005.05683.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:800 / 801
页数:2
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共 6 条
  • [1] Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    Baxter, EJ
    Scott, LM
    Campbell, PJ
    East, C
    Fourouclas, N
    Swanton, S
    Vassiliou, GS
    Bench, AJ
    Boyd, EM
    Curtin, N
    Scott, MA
    Erber, WN
    Green, AR
    [J]. LANCET, 2005, 365 (9464) : 1054 - 1061
  • [2] Familial polycythemia vera with Budd-Chiari syndrome in childhood
    Cario, H
    Pahl, HL
    Schwarz, K
    Galm, C
    Hoffmann, M
    Burdelski, M
    Kohne, E
    Debatin, KM
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2003, 123 (02) : 346 - 352
  • [3] A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    James, C
    Ugo, V
    Le Couédic, JP
    Staerk, J
    Delhommeau, F
    Lacout, C
    Garçon, L
    Raslova, H
    Berger, R
    Bennaceur-Griscelli, A
    Villeval, JL
    Constantinescu, SN
    Casadevall, N
    Vainchenker, W
    [J]. NATURE, 2005, 434 (7037) : 1144 - 1148
  • [4] Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease
    Kralovics, R
    Stockton, DW
    Prchal, JT
    [J]. BLOOD, 2003, 102 (10) : 3793 - 3796
  • [5] A gain-of-function mutation of JAK2 in myeloproliferative disorders
    Kralovics, R
    Passamonti, F
    Buser, AS
    Teo, S
    Tiedt, R
    Passweg, JR
    Tichelli, A
    Cazzola, M
    Skoda, RC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (17) : 1779 - 1790
  • [6] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    Levine, RL
    Wadleigh, M
    Cools, J
    Ebert, BL
    Wernig, G
    Huntly, BJP
    Boggon, TJ
    Wlodarska, L
    Clark, JJ
    Moore, S
    Adelsperger, J
    Koo, S
    Lee, JC
    Gabriel, S
    Mercher, T
    D'Andrea, A
    Fröhling, S
    Döhner, K
    Marynen, P
    Vandenberghe, P
    Mesa, RA
    Tefferi, A
    Griffin, JD
    Eck, MJ
    Sellers, WR
    Meyerson, M
    Golub, TR
    Lee, SJ
    Gilliland, DG
    [J]. CANCER CELL, 2005, 7 (04) : 387 - 397