Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates

被引:18
作者
Brissaud, O
Chateil, JF
Bordessoules, M
Brun, M
机构
[1] Childrens Hosp, Paediat Intens Care Unit, F-33076 Bordeaux, France
[2] Childrens Hosp, Radiol Unit, F-33076 Bordeaux, France
关键词
brain; asphyxia; MRI; MRS; DWI; neonates;
D O I
10.1007/s00247-005-1524-5
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Diagnosis of brain lesions after birth anoxia-ischemia is essential for appropriate management. Clinical evaluation is not sufficient. MRI has been proven to provide useful information. Objective: To compare abnormalities observed with MRI, including diffusion-weighted imaging (DWI), localised magnetic resonance spectroscopy (MRS) and chemical shift imaging (CSI) and correlate these findings with the clinical outcome. Materials and methods: Fourteen full-term neonates with birth asphyxia were studied. MRI, MRS and CSI were performed within the first 4 days of life. Results: Lesions observed with DWI were correlated with outcome, but the apparent diffusion coefficient (ADC) did improve diagnostic confidence. The mean value of Lac/Cr for the neonates with a favourable outcome was statically lower than for those who died (0.22 vs 1.04; P = 0.01). The same results were observed for the Lac/NAA ratio (0.21 vs 1.23; P = 0.01). Data obtained with localised MRS and CSI were correlated for the ratio N-acetyl-aspartate/choline, but not for the other metabolites. No correlation was found between the ADC values and the metabolite ratios. Conclusions: Combination of these techniques could be helpful in our understanding of the physiopathological events occurring in neonates with asphyxia.
引用
收藏
页码:998 / 1005
页数:8
相关论文
共 22 条
[1]  
AMIELTISON C, 1986, DEV MED CHILD NEUROL, V28, P671
[2]   Feasibility of proton chemical shift imaging with a stereotactic headframe [J].
Baik, HM ;
Choe, BY ;
Son, BC ;
Kim, MC ;
Kim, EN ;
Lee, HK ;
Suh, TS .
MAGNETIC RESONANCE IMAGING, 2003, 21 (01) :55-59
[3]  
Barkovich AJ, 1999, AM J NEURORADIOL, V20, P1399
[4]  
Barkovich AJ, 1998, AM J NEURORADIOL, V19, P143
[5]  
DEDIOS JG, 1996, REV NEUROL, V24, P812
[6]   Hypoxia-ischemic encephalopathy in full-term neonate: correlation proton MR spectroscopy with MR imaging [J].
Fan, GG ;
Wu, ZH ;
Chen, LY ;
Guo, QY ;
Ye, BB ;
Mao, J .
EUROPEAN JOURNAL OF RADIOLOGY, 2003, 45 (02) :91-98
[7]  
Forbes KPN, 2000, AM J NEURORADIOL, V21, P1490
[8]   Hypoxic-ischemic encephalopathy in the term newborn. Contribution of the electroencephalogram and magnetic resonance imaging (MRI) or computed tomography scan (CTS) to the prognostic assessment. A review of 26 cases. [J].
Gire, C ;
Nicaise, C ;
Roussel, M ;
Soula, F ;
Girard, N ;
Somma-Mauvais, H ;
Lagier, P ;
Dejode, JM ;
Farnarier, G ;
Garnier, JM .
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, 2000, 30 (02) :97-107
[9]   Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor [J].
Harada, M ;
Uno, M ;
Hong, F ;
Hisaoka, S ;
Nishitani, H ;
Matsuda, T .
NMR IN BIOMEDICINE, 2002, 15 (01) :69-74
[10]   Proton Magnetic Resonance Spectroscopy Improves Outcome Prediction in Perinatal CNS Insults [J].
Munaf Kadri ;
Stanford Shu ;
Barbara Holshouser ;
Douglas Deming ;
Andrew Hopper ;
Ricardo Peverini ;
Stephen Ashwal .
Journal of Perinatology, 2003, 23 (3) :181-185