NEMO/IKKγ:: Linking NF-κB to human disease

被引：60

作者：

Courtois, G ^{[1
]}

Smahi, A

Israël, A

机构：

[1] Inst Pasteur, CNRS, URA 1773, Unite Biol Mol Express Genique, Paris, France

[2] Hop Necker Enfants Malad, INSERM, Unite Rech Handicaps Genet Enfant, U393, Paris, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 10期

关键词：

D O I：

10.1016/S1471-4914(01)02154-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Until recently, no genetic disease caused by NF-kappaB dysfunction was known. This changed with the identification of the X-linked gene encoding a molecule of the NF-kappaB signaling pathway, NEMO/IKK gamma Two distinct X-linked human diseases, incontinentia pigmenti (IP) and anhidrotic ectodermal dysplasia associated with immunodeficiency (EDA-ID), have been linked to NEMO/IKK gamma dysfunction, providing a unique view of the role that NF-kappaB plays in human development, skin homeostasis and innate and acquired immunity.

引用

页码：427 / 430

页数：4

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