A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2

被引：195
作者：
Atzrodt, Cassandra L. [1 ]
Maknojia, Insha [1 ]
McCarthy, Robert D. P. [1 ]
Oldfield, Tiara M. [1 ]
Po, Jonathan [1 ]
Ta, Kenny T. L. [1 ]
Stepp, Hannah E. [1 ]
Clements, Thomas P. [1 ]
机构：
[1] Vanderbilt Univ, Dept Biol Sci, 1210 Biol Sci MRB,465 21st St South, Nashville, TN 37235 USA
来源：
FEBS JOURNAL | 2020年 / 287卷 / 17期
关键词：
ACE2; coronavirus; COVID-19; CRISPR; MERS; MERS-CoV; SARS; SARS-CoV; SARS-CoV-2; vaccine; SPIKE PROTEIN; SARS-COV; 2019-NCOV; PATHOGENESIS; PCR; EPIDEMIOLOGY; TRANSMISSION; MECHANISMS; INHIBITION; MANAGEMENT;
D O I：
10.1111/febs.15375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The emergence of the SARS-CoV-2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID-19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS-CoV-2 has characteristics of past human coronaviruses, with close genomic similarities to SARS-CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS-CoV-2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus - with vaccine trials underway in the United States and the United Kingdom - and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS-CoV-2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines.
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收藏
页码：3633 / 3650
页数：18
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