Background Atopic dermatitis (AD) is a multifactorial inflammatory skin disease with frequent hypersensitivity to allergens. However, the role of exposure to indoor allergens on AD severity is unclear. Methods Children aged 0-17 years with active AD from central Chile were recruited; disease severity was evaluated with SCORAD and POEM scores. A home environment survey was applied to parents. Bedroom dust samples were collected for all subjects and analyzed by multiplex assay to quantify dust mite (Der p1, Der f1), dog (Can f1), cat (Fel d1), and alternaria alternata (Alt a1) allergens. Results Twenty-five children aged 3.9 +/- 3.8 years were included. Fifty-two percent were female. Mean SCORAD was 29 +/- 14 (range 11-61), and mean POEM was 10.7 +/- 6.2. No direct association was found between tobacco exposure, pet ownership, aerosol use, visible dust, or home carpets/rugs with SCORAD (all P > 0.05). Dust samples from all homes had Can f1 and Fel d1 allergens, regardless of pet ownership. Homes that had indoor dogs or cats had significantly higher amounts of these allergens (P < 0.001). Forty percent of homes had dust mite allergens, and none had alternaria alternata. Children with AD living in homes with elevated dust mite and animal dander allergen concentrations had higher SCORAD than those from homes with low allergen concentrations (40 +/- 13 vs. 26 +/- 13, P = 0.025). Conclusions High concentrations of indoor allergens may influence AD severity in children. Further studies assessing indoor allergens and allergen sensitization are warranted to fully evaluate the role of indoor allergens on AD.
机构:
Korea Univ, Coll Med, Seoul 136705, South Korea
Korea Univ, Med Ctr, Environm Hlth Ctr Asthma, Seoul, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Seo, S.
Kim, J.
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Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Environm Hlth Ctr Atop Dermatitis, Seoul, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Kim, J.
Han, Y.
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Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Environm Hlth Ctr Atop Dermatitis, Seoul, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Han, Y.
Ahn, K.
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Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Environm Hlth Ctr Atop Dermatitis, Seoul, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Ahn, K.
Yoo, Y.
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Korea Univ, Med Ctr, Environm Hlth Ctr Asthma, Seoul, South Korea
Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Yoo, Y.
Choung, J. T.
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Korea Univ, Med Ctr, Environm Hlth Ctr Asthma, Seoul, South Korea
Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Choung, J. T.
J-H, Lee
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Univ Ulsan, Med Ctr, Ctr Environm Hlth, Ulsan 680749, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
机构:
George Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Silverberg, Jonathan I.
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Lei, Donald
Yousaf, Muhammad
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Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Yousaf, Muhammad
Janmohamed, Sherief R.
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机构:
Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Janmohamed, Sherief R.
Vakharia, Paras P.
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Univ Texas Southwestern Med Ctr Dallas, Dept Dermatol, Dallas, TX USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Vakharia, Paras P.
Chopra, Rishi
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Suny Downstate Med Ctr, Brooklyn, NY 11203 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Chopra, Rishi
Chavda, Rajeev
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Galderma SA, Rx Strategy & Innovat Grp, La Tour De Peliz, SwitzerlandGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Chavda, Rajeev
Gabriel, Sylvie
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Galderma SA, Rx Strategy & Innovat Grp, La Tour De Peliz, SwitzerlandGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Gabriel, Sylvie
Patel, Kevin R.
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Massachusetts Gen Hosp, Dept Internal Med, Boston, MA 02114 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Patel, Kevin R.
Singam, Vivek
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Weiss Mem Hosp, Dept Internal Med, Chicago, IL USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Singam, Vivek
Kantor, Robert
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Suny Downstate Med Ctr, Brooklyn, NY 11203 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Kantor, Robert
Hsu, Derek Y.
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Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
Hsu, Derek Y.
Cella, David
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Northwestern Univ, Feinberg Sch Med, Dept Med Social Sci, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Dermatol, Suite 2B-425,2150 Penn Ave, Washington, DC 20037 USA
机构:
St Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA
Beth Israel Deaconess Med Ctr, New York, NY 10025 USASt Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA
Silverberg, J. I.
Silverberg, N. B.
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机构:
St Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA
Beth Israel Deaconess Med Ctr, New York, NY 10025 USASt Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA
Silverberg, N. B.
Lee-Wong, M.
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Beth Israel Deaconess Med Ctr, Dept Allergy & Immunol, New York, NY 10003 USASt Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA