A highly selective and sensitive spectrofluorimetric method for the assessment of 3-nitrotyrosine in serum using (Eu(TTA)3Phen) photo probe

被引：1

作者：

Attia, Mohmed S. ^{[1
]}

Youssef, Ahmed O. ^{[1
]}

Abdel-Sattar, Nour A. ^{[1
]}

Amin, Mohammed A. ^{[2
]}

Alharthi, Sarah ^{[2
]}

Mohamed, Ekram H. ^{[3
]}

Mahmoud, Safwat A. ^{[4
]}

Abou-Omar, Mona N. ^{[5
]}

机构：

[1] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt

[2] Taif Univ, Coll Sci, Dept Chem, POB 11099, At Taif 21944, Saudi Arabia

[3] British Univ Egypt, Fac Pharm, Pharmaceut Chem Dept, Cairo, Egypt

[4] Northern Border Univ, Fac Sci, Phys Dept, Ar Ar, Saudi Arabia

[5] Ain Shams Univ, Fac Women Arts Sci & Educ, Dept Chem, Cairo, Egypt

来源：

RSC ADVANCES | 2022年 / 12卷 / 08期

关键词：

OPTICAL SENSOR; MASS-SPECTROMETRY; EARLY-DIAGNOSIS; HUMAN PLASMA; HEPATIC-ENCEPHALOPATHY; HUMAN URINE; QUANTIFICATION; ENHANCEMENT; DISEASES; NITRATION;

D O I：

10.1039/d1ra07351f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, accurate and fast method was developed for the assessment of 3-nitrotyrosine as a biomarker for the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy (MHE) using a (Eu(TTA)(3)Phen) photo probe. 3-Nitrotyrosine can remarkably quench the luminescence intensity of the (Eu(TTA)(3)Phen) complex in DMSO at pH = 9 and lambda(em) = 617 nm. The quenching of the luminescence intensity of (Eu(TTA)(3)Phen) complex particularly the electrical emission band at lambda(em) = 617 nm is used for the assessment of 3-nitrotyrosine in different serum samples of patients with liver cirrhosis.

引用

页码：4536 / 4542

页数：7

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