Adsorption of calcitonin to glass

被引：16

作者：

Law, SL ^{[1
]}

Shih, CL ^{[1
]}

机构：

[1] Vet Gen Hosp, Dept Med Res, Pharmaceut Res Lab, Taipei 11217, Taiwan

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 02期

关键词：

D O I：

10.1081/DDC-100102168

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Surface adsorption of calcitonin on soda lime silica glass was investigated An attempt was also made to examine the effect of additives on the inhibition of calcitonin adsorption. Results showed that the adsorption isotherms were of the Langmuir and Freundlich type, depending on pH. Less adsorption was found for calcitonin at pH, 4.3. The addition of nonionic surfactants such as Pluronic F68 and Tween 80 to the calcitonin solutions demonstrated inhibition of adsorption and reduction of adsorption rate. The addition of chlorobutanol also showed the effect of minimizing adsorption.

引用

页码：253 / 256

页数：4

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