GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-7-5p in pancreatic cancer

被引：57

作者：

Gu, Jiangning ^{[1
,2
,3
]}

Wang, Di ^{[4
]}

Zhang, Jiaqiang ^{[1
,3
]}

Zhu, Yi ^{[1
,5
]}

Li, Ying ^{[2
]}

Chen, Hao ^{[1
,3
]}

Shi, Minmin ^{[3
]}

Wang, Xuelong ^{[2
]}

Shen, Baiyong ^{[1
,3
]}

Deng, Xiaxing ^{[1
,3
]}

Zhan, Qian ^{[1
,3
]}

Wei, Gang ^{[2
]}

Peng, Chenghong ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, PICB, MPG,Key Lab Computat Biol, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Res Inst Digest Surg, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai First Peoples Hosp, Dept Prophylact Med, Shanghai, Peoples R China

[5] Zhejiang Univ, Second Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2016年 / 380卷 / 02期

基金：

美国国家科学基金会;

关键词：

GFR alpha 2; PTEN; Mir-17-5p; Chemoresistance; Pancreatic cancer; DUCTAL ADENOCARCINOMA; NEUROTROPHIC FACTOR; NEUROPATHIC PAIN; GEMCITABINE; EXPRESSION; SURVIVAL; PLASTICITY; MICRORNA;

D O I：

10.1016/j.canlet.2016.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nerve growth factors and their receptors have received an increasing attention in certain cancers since they play an important role in regulating tumorigenesis, biological process and metastasis. Here we aimed at characterizing a new function of one of the subtypes of growth factor receptors (GFR), GFR alpha(2), in pancreatic cancer. In this study, we showed that GFR alpha(2) was up-regulated in pancreatic adenocarcinoma and was positively correlated with tumor size and perineural invasion, which indicated that it may be associated with cell growth and apoptosis. Mechanically, we discovered that high GFR alpha(2) expression level leads to PTEN inactivation via enhancing Mir-17-5p level. (C) 2016 The Author(s). Published by Elsevier Ireland Ltd.

引用

页码：434 / 441

页数：8

共 32 条

[1] Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial [J].

Burris, HA ;

Moore, MJ ;

Andersen, J ;

Green, MR ;

Rothenberg, ML ;

Madiano, MR ;

Cripps, MC ;

Portenoy, RK ;

Storniolo, AM ;

Tarassoff, P ;

Nelson, R ;

Dorr, FA ;

Stephens, CD ;

VanHoff, DD .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2403-2413

[2] Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells [J].

Chen, Jiangzhi ;

Xu, Hong ;

Zou, Xiuqun ;

Wang, Jiamin ;

Zhu, Yi ;

Chen, Hao ;

Shen, Baiyong ;

Deng, Xiaxing ;

Zhou, Aiwu ;

Chin, Y. Eugene ;

Rauscher, Frank J., III ;

Peng, Chenghong ;

Hou, Zhaoyuan .

CANCER RESEARCH, 2014, 74 (16) :4353-4363

[3] FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer [J].

Conroy, Thierry ;

Desseigne, Francoise ;

Ychou, Marc ;

Bouche, Olivier ;

Guimbaud, Rosine ;

Becouarn, Yves ;

Adenis, Antoine ;

Raoul, Jean-Luc ;

Gourgou-Bourgade, Sophie ;

de la Fouchardiere, Christelle ;

Bennouna, Jaafar ;

Bachet, Jean-Baptiste ;

Khemissa-Akouz, Faiza ;

Pere-Verge, Denis ;

Delbaldo, Catherine ;

Assenat, Eric ;

Chauffert, Bruno ;

Michel, Pierre ;

Montoto-Grillot, Christine ;

Ducreux, Michel .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19) :1817-1825

[4] miRNAs in the spotlight: Understanding cancer gene dependency [J].

Croce, Carlo M. .

NATURE MEDICINE, 2011, 17 (08) :935-936

[5] Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics [J].

Crockett, DK ;

Fillmore, GC ;

Elenitoba-Johnson, KSJ ;

Lim, MS .

PROTEOMICS, 2005, 5 (05) :1250-1262

[6] Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer [J].

Dhar, Swati ;

Kumar, Avinash ;

Rimando, Agnes M. ;

Zhang, Xu ;

Levenson, Anait S. .

ONCOTARGET, 2015, 6 (29) :27214-27226

[7] MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II [J].

Dhayat, Sameer Abdallah ;

Abdeen, Baha ;

Koehler, Gabriele ;

Senninger, Norbert ;

Haier, Joerg ;

Mardin, Wolf Arif .

CLINICAL EPIGENETICS, 2015, 7

[8] MicroRNA-17-5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling [J].

Fang, Ying ;

Xu, Changyan ;

Fu, Yan .

JOURNAL OF BIOLOGICAL RESEARCH-THESSALONIKI, 2015, 22

[9] Insights into regulation of the miR-17-92 cluster of miRNAs in cancer [J].

Fuziwara, Cesar Seigi ;

Kimura, Edna Teruko .

FRONTIERS IN MEDICINE, 2015, 2

[10] A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary [J].

Garcia-Lavandeira, Montse ;

Quereda, Victor ;

Flores, Ignacio ;

Saez, Carmen ;

Diaz-Rodriguez, Esther ;

Japon, Miguel A. ;

Ryan, Aymee K. ;

Blasco, Maria A. ;

Dieguez, Carlos ;

Malumbres, Marcos ;

Alvarez, Clara V. .

PLOS ONE, 2009, 4 (03)

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