Defective T Cell Chemotaxis to Sphingosine 1-Phosphate and Chemokine CCL21 in Idiopathic T Lymphocytopenia

被引：4

作者：

Goetzl, Edward J. ^{[1
,2
,3
]}

Schwartz, Janice B. ^{[2
,3
]}

Huang, Mei-Chuan ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Geriatr Res Ctr, San Francisco, CA 94115 USA

[2] Univ Calif San Francisco, Dept Med, Geriatr Res Ctr, San Francisco, CA 94112 USA

[3] Univ Calif San Francisco, Dept Microbiol Immunol, Geriatr Res Ctr, San Francisco, CA 94112 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2011年 / 31卷 / 05期

关键词：

Human; T lymphocytes; chemotaxis; lipid mediator; chemokines; MICE LACKING EXPRESSION; G-PROTEIN; EGRESS; RECEPTORS; INTERLEUKIN-2; TRAFFICKING;

D O I：

10.1007/s10875-011-9554-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell chemotaxis to sphingosine 1-phosphate (S1P) and the chemokines CCL21 and CCL5 was studied in ten adults with T lymphocytopenia, other immunological abnormalities (nine of ten), and frequent bacterial infections (seven of ten). Mean chemotactic responses to S1P of CD4 T cells from CD4 T lymphocytopenic patients and of CD8 T cells from CD8 T lymphocytopenic patients were significantly lower than those of healthy matched controls. Chemotaxis to CCL21 was lower than that of controls for CD4 T cells of three CD4 T lymphocytopenic patients and for CD8 T cells of three CD8 T lymphocytopenic patients, but none of the T cells of patients had diminished chemotaxis to CCL5. Defective T cell chemotactic responses to S1P and some chemokines may lead to subset-selective abnormal T cell trafficking and chronic T cell lymphocytopenia.

引用

页码：744 / 751

页数：8

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