Maternal smoking and pulmonary neuroendocrine cells in sudden infant death syndrome

被引:0
|
作者
Cutz, E [1 ]
Perrin, DG [1 ]
Hackman, R [1 ]
CzegledyNagy, EN [1 ]
机构
[1] UNIV TORONTO,TORONTO,ON,CANADA
关键词
airway chemoreceptor; oxygen sensing; nicotine;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background. Maternal smoking is a well-recognized risk factor for sudden infant death syndrome (SIDS), but the precise mechanism is unknown. We tested a hypothesis that maternal smoking affects pulmonary neuroendocrine cells (PNECs) and neuroepithelial bodies (NEBs), which are innervated PNEC clusters and presumed airway chemoreceptors. Methods. Lung sections from infants who died of SIDS and whose mothers smoked during pregnancy (n = 22), infants who died of SIDS and whose mothers were nonsmokers (n = 17), ahd age-matched control infants (n = 15) who died of other causes were immunostained for bombesin (a PNEC and NEB marker) and assessed morphometrically. Results. The frequency of PNEC (the percentage of airway epithelium immunoreactive for bombesin) was increased up to twofold in the lungs of infants who died of SIDS (7.7 +/- 0.4%) compared with controls (4.9 +/- 0.4%), as was the frequency (40 +/- 3.5 vs 23 +/- 3.7/cm(2)) and size (748 +/- 46.5 vs 491 +/- 25.8 mu m(2)) of NEBs. In infants who died of SIDS and who were born to smoking mothers, PNEC frequency was increased significantly compared with that in those born to nonsmoking mothers, but the frequency and size of NEBs were not significantly different between the two groups. Conclusion. Our findings suggest that maternal smoking potentiates hyperplasia of the PNEC system in the lungs of infants who die of SIDS and that a dysfunction of these cells may contribute to the pathophysiology of SIDS.
引用
收藏
页码:668 / 672
页数:5
相关论文
共 50 条
  • [21] Association of maternal snuff use and smoking with Sudden Infant Death Syndrome: a national register study
    Gunnerbeck, Anna
    Lundholm, Cecilia
    Rhedin, Samuel
    Mitha, Ayoub
    Chen, Ruoqing
    D'Onofrio, Brian M.
    Almqvist, Catarina
    PEDIATRIC RESEARCH, 2023, 94 (02) : 811 - 819
  • [22] EFFECT OF MATERNAL CIGARETTE-SMOKING ON PREGNANCY COMPLICATIONS AND SUDDEN-INFANT-DEATH-SYNDROME
    DIFRANZA, JR
    LEW, RA
    JOURNAL OF FAMILY PRACTICE, 1995, 40 (04): : 385 - 394
  • [23] SUDDEN-INFANT-DEATH-SYNDROME IN SWEDEN, 1983-1990 - SEASON AT DEATH, AGE AT DEATH, AND MATERNAL SMOKING
    HAGLUND, B
    CNATTINGIUS, S
    OTTERBLADOLAUSSON, P
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 1995, 142 (06) : 619 - 624
  • [24] Smoking and sudden infant death
    不详
    ADDICTION, 1999, 94 (03) : 452 - 452
  • [25] Biopathology of the dentate-olivary complex in sudden unexplained perinatal death and sudden infant death syndrome related to maternal cigarette smoking
    Lavezzi, Anna Maria
    Ottaviani, Giulia
    Mauri, Maria
    Matturri, Luigi
    NEUROLOGICAL RESEARCH, 2007, 29 (06) : 525 - 532
  • [26] SIMILAR PULMONARY NEUROENDOCRINE CELL ABNORMALITY IN SUDDEN UNEXPLAINED NEONATAL DEATH AND SUDDEN-INFANT-DEATH-SYNDROME SUGGESTS IDENTICAL PATHOPHYSIOLOGY
    FEAKINS, R
    KELEHAN, P
    GILLAN, JE
    LABORATORY INVESTIGATION, 1993, 68 (01) : P3 - P3
  • [27] Racial differences in the impact of maternal smoking on sudden unexpected infant death
    Ostfeld, Barbara M.
    Schwartz-Soicher, Ofira
    Reichman, Nancy E.
    Hegyi, Thomas
    JOURNAL OF PERINATOLOGY, 2023, 43 (03) : 345 - 349
  • [28] PULMONARY EOSINOPHILIA IN SUDDEN-INFANT-DEATH-SYNDROME
    BAXENDINE, JA
    MOORE, IE
    JOURNAL OF PATHOLOGY, 1995, 177 (04): : 415 - 421
  • [29] PULMONARY ARTERIAL ABNORMALITIES IN SUDDEN INFANT DEATH SYNDROME
    NAEYE, RL
    NEW ENGLAND JOURNAL OF MEDICINE, 1973, 289 (22): : 1167 - 1170
  • [30] PULMONARY VASCULAR CHANGES IN SUDDEN INFANT DEATH SYNDROME
    KENDEEL, SR
    FERRIS, JAJ
    ARCHIVES OF DISEASE IN CHILDHOOD, 1977, 52 (06) : 512 - 512