Ring expansion: formal total synthesis of (-)-paroxetine

被引：38
作者：
Cossy, J
Mirguet, O
Pardo, DG
Desmurs, JR
机构：
[1] Ecole Super Phys & Chim Ind Ville Paris, CNRS, Chim Organ Lab, F-75231 Paris 05, France
[2] Rhodia, F-69457 Lyon 06, France
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 33期
关键词：
D O I：
10.1016/S0040-4039(01)01096-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. A stereoselective ring expansion of prolinol generated the Substituted piperidine ring precursor of (-)-paroxetine. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：5705 / 5707
页数：3
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