Steroidal glycosides from the rhizomes of Ruscus hypophyllum

被引：11

作者：

Mimaki, Yoshihiro ^{[1
]}

Aoki, Tsukasa ^{[1
]}

Jitsuno, Maki ^{[1
]}

Kilic, Ceyda Sibel ^{[2
]}

Coskun, Maksut ^{[2
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Ankara Univ, Fac Pharm, TR-06100 Ankara, Turkey

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 03期

关键词：

Ruscus hypophyllum; Liliaceae; glycosides; spirostanol saponins; cholestane glycosides;

D O I：

10.1016/j.phytochem.2007.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven steroidal glycosides, along with one known glycoside, were isolated from the rhizomes of Ruscus hypophyllum (Liliaceae). Comprehensive spectroscopic analysis, including 2D NMR spectroscopy, and the results of acid hydrolysis allowed the chemical structures of the compounds to be assigned as (23S,25R)-23-hydroxyspirost-5-en-3 beta-yl O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranoside (1), 1 beta-hydroxyspirosta-5,25(27)-dien-3-beta-yl O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranoside (2), (22S)-16 beta,22-dihydroxycholest-5en-3 beta-yl O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranoside (3), (22S)-16 beta-[(beta-D-glucopyranosyl)oxy]-22-hydroxycholest-5-en-3 beta-yl O-alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranoside (4), (22S)-16 beta-[(beta-D-glucopyranosyl)oxy]-22-hydroxycholest-5-en-3 beta-yl beta-D-glucopyranoside (5), (22S)-16 beta-[(beta-D-glucopyranosyl)oxy]-3 beta,22-dihydroxycholest-5-en-1 beta-yl O-alpha-L-rhamnopyranosyl-(1 -> 2)-(3,4-di-O-acetyl-beta-D-xylopyranoside) (6), and (22S)-16 beta-[(beta-D-glucopyranosyl)oxy]-3 beta,22-dihydroxycholest-5-en-1 beta-yl O-alpha-L-rhamnopyranosyl(1 -> 2)-O-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-xylopyranoside (7), respectively. This is the first isolation of a series of cholestane glycosides from a Ruscus species. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：729 / 737

页数：9

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