Trends of hepatitis B virus genotype distribution in chronic hepatitis B patients in Japan

被引：3

作者：

Sakamoto, Kazumasa ^{[1
]}

Ito, Kiyoaki ^{[1
]}

Yotsuyanagi, Hiroshi ^{[2
,3
]}

Yatsuhashi, Hiroshi ^{[4
]}

Tanaka, Yasuhito ^{[5
]}

Hige, Shuhei ^{[6
]}

Takikawa, Yasuhiro ^{[7
]}

Ueno, Yoshiyuki ^{[8
]}

Yamamoto, Kazuhide ^{[9
]}

Imazeki, Fumio ^{[10
]}

Inoue, Jun ^{[11
]}

Kurosaki, Masayuki ^{[12
]}

Umemura, Takeji ^{[13
]}

Toyoda, Hidenori ^{[14
]}

Mita, Eiji ^{[15
]}

Michitaka, Kojiro ^{[16
]}

Maeshiro, Tatsuji ^{[17
]}

Yamada, Norie ^{[18
]}

Suetsugu, Atsushi ^{[19
]}

Kawanaka, Miwa ^{[20
]}

Seko, Yuya ^{[21
]}

Matsuura, Kentaro ^{[22
]}

Okumura, Akinori ^{[1
]}

Fukuzawa, Yoshitaka ^{[1
]}

Sugiyama, Masaya ^{[23
]}

Mizokami, Masashi ^{[24
]}

Yoneda, Masashi ^{[1
]}

机构：

[1] Aichi Med Univ, Dept Gastroenterol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Univ Tokyo, Adv Clin Res Ctr, Inst Med Sci, Div Infect Dis, Tokyo, Japan

[3] Univ Tokyo, IMSUT Hosp, Dept Infect Dis & Appl Immunol, Inst Med Sci, Tokyo, Japan

[4] Natl Hosp Org Nagasaki Med Ctr, Clin Res Ctr, Dept Hepatol, Nagasaki, Japan

[5] Kumamoto Univ, Fac Life Sci, Dept Gastroenterol & Hepatol, Kumamoto, Japan

[6] Sapporo Kosei Gen Hosp, Dept Gastroenterol, Sapporo, Hokkaido, Japan

[7] Iwate Med Univ, Dept Internal Med, Morioka, Iwate, Japan

[8] Yamagata Univ, Fac Med, Dept Gastroenterol, Yamagata, Japan

[9] Okayama Saiseikai Gen Hosp, Dept Internal Med, Okayama, Japan

[10] Chiba Univ, Safety & Hlth Org, Chiba, Japan

[11] Tohoku Univ, Div Gastroenterol, Grad Sch Med, Sendai, Miyagi, Japan

[12] Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Musashino, Tokyo, Japan

[13] Shinshu Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, Matsumoto, Nagano, Japan

[14] Ogaki Municipal Hosp, Dept Gastroenterol, Ogaki, Japan

[15] Natl Hosp Org Osaka Natl Hosp, Dept Gastroenterol & Hepatol, Osaka, Japan

[16] Ehime Prefectural Cent Hosp, Gastroenterol Ctr, Matsuyama, Ehime, Japan

[17] Univ Ryukyus, Grad Sch Med, Dept Infect Resp & Digest Med, Nishihara, Okinawa, Japan

[18] Seizankai Kiyokawa Hosp, Ctr Liver Dis, Dept Internal Med, Tokyo, Japan

[19] Gifu Univ, Dept Gastroenterol, Grad Sch Med, Gifu, Japan

[20] Kawasaki Med Sch, Dept Gen Internal Med 2, Okayama, Japan

[21] Kyoto Prefectural Univ Med, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[22] Nagoya City Univ, Dept Gastroenterol & Metab, Grad Sch Med Sci, Nagoya, Aichi, Japan

[23] Natl Ctr Global Hlth & Med, Dept Viral Pathogenesis & Controls, Ichikawa, Japan

[24] Natl Ctr Global Hlth & Med, Genome Med Sci Project, Ichikawa, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2022年 / 57卷 / 12期

关键词：

Hepatitis B virus; Genotype; Geographical distribution; Trend of genotype; Chronic hepatitis B; SURFACE-ANTIGEN; ACTIVE IMMUNOPROPHYLAXIS; GENETIC DIVERSITY; INFECTION; TRANSMISSION; PERSISTENCE; SEQUENCES;

D O I：

10.1007/s00535-022-01921-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B and C account for most of acute and chronic cases of hepatitis. However, previous studies showed that the prevalence of genotype A in CHB gradually increased every 5 years. Therefore, we have conducted a nationwide survey to comprehensively investigate the trends of HBV genotype distribution in CHB patients in Japan. Methods 4421 CHB patients were recruited between 2015 and 2016. Clinical characteristics and distribution of CHB patients among different age groups and genotypes in 2015-2016 was compared with those in 2000-2001, 2005-2006, and 2010-2011. Results The percentages of genotype A, B, C, and D were 4.0, 16.2, 79.1, and 0.7%, respectively. While the overall percentage of CHB patients with genotype A did not change in the past 5 years, CHB with genotype A increased in young adults. On the other hand, the peak distribution of CHB with genotypes B and C, two genotypes with the largest patient population, has shifted to an older age group. Conclusions In Japan, the peak distribution for CHB with genotypes B and C advanced to an older age group while CHB with genotype A expanded in a younger age group. Given the universal HBV vaccination launch in Japan in 2016, these pre-vaccination survey data provide important baseline information for comparative studies of the impact of universal vaccination on HBV genotypes.

引用

页码：971 / 980

页数：10

共 25 条

[1]

Anonymous, 2007, Morbidity and Mortality Weekly Report, V56, P441

[2]

[Anonymous], 2009, Hepatitis B vaccines: WHO position paper, V84, P405

[3] Factors That Predict Response of Patients With Hepatitis B e Antigen-Positive Chronic Hepatitis B to Peginterferon-Alfa [J].

Buster, Erik H. C. J. ;

Hansen, Bettina E. ;

Lau, George K. K. ;

Piratvisuth, Teerha ;

Zeuzem, Stefan ;

Steyerberg, Ewout W. ;

Janssen, Harry L. A. .

GASTROENTEROLOGY, 2009, 137 (06) :2002-2009

[4]

Horai S, 1996, AM J HUM GENET, V59, P579

[5]

Ito, 2018, TRENDS MOL BIOL ANAL, P1

[6] Comparison of complete sequences of hepatitis B virus genotype C between inactive carriers and hepatocellular carcinoma patients before and after seroconversion [J].

Ito, Kiyoaki ;

Tanaka, Yasuhito ;

Kato, Michio ;

Fujiwara, Kei ;

Sugauchi, Fuminaka ;

Sakamoto, Tomoyuki ;

Shinkai, Noboru ;

Orito, Etsuro ;

Mizokami, Masashi .

JOURNAL OF GASTROENTEROLOGY, 2007, 42 (10) :837-844

[7]

Ito K, 2018, J GASTROENTEROL, V53, P18, DOI 10.1007/s00535-017-1367-5

[8] Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan [J].

Ito, Kiyoaki ;

Yotsuyanagi, Hiroshi ;

Sugiyama, Masaya ;

Yatsuhashi, Hiroshi ;

Karino, Yoshiyasu ;

Takikawa, Yasuhiro ;

Saito, Takafumi ;

Arase, Yasuji ;

Imazeki, Fumio ;

Kurosaki, Masayuki ;

Umemura, Takeji ;

Ichida, Takafumi ;

Toyoda, Hidenori ;

Yoneda, Masashi ;

Tanaka, Yasuhito ;

Mita, Eiji ;

Yamamoto, Kazuhide ;

Michitaka, Kojiro ;

Maeshiro, Tatsuji ;

Tanuma, Junko ;

Korenaga, Masaaki ;

Murata, Kazumoto ;

Masaki, Naohiko ;

Koike, Kazuhiko ;

Mizokami, Masashi .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 (01) :180-189

[9] Risk Factors for Long-Term Persistence of Serum Hepatitis B Surface Antigen Following Acute Hepatitis B Virus Infection in Japanese Adults [J].

Ito, Kiyoaki ;

Yotsuyanagi, Hiroshi ;

Yatsuhashi, Hiroshi ;

Karino, Yoshiyasu ;

Takikawa, Yasuhiro ;

Saito, Takafumi ;

Arase, Yasuji ;

Imazeki, Fumio ;

Kurosaki, Masayuki ;

Umemura, Takeji ;

Ichida, Takafumi ;

Toyoda, Hidenori ;

Yoneda, Masashi ;

Mita, Eiji ;

Yamamoto, Kazuhide ;

Michitaka, Kojiro ;

Maeshiro, Tatsuji ;

Tanuma, Junko ;

Tanaka, Yasuhito ;

Sugiyama, Masaya ;

Murata, Kazumoto ;

Masaki, Naohiko ;

Mizokami, Masashi .

HEPATOLOGY, 2014, 59 (01) :89-97

[10] Characterization of Genotype-Specific Carboxyl-Terminal Cleavage Sites of Hepatitis B Virus e Antigen Precursor and Identification of Furin as the Candidate Enzyme [J].

Ito, Kiyoaki ;

Kim, Kyun-Hwan ;

Lok, Anna Suk-Fong ;

Tong, Shuping .

JOURNAL OF VIROLOGY, 2009, 83 (08) :3507-3517

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