Steroids and spinal cord injury: Revisiting the NASCIS 2 and NASCIS 3 trials

被引：157
作者：
Nesathurai, S
机构：
[1] Boston Med Ctr, New England Reg Spinal Cord Ctr, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Boston, MA 02118 USA
来源：
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | 1998年 / 45卷 / 06期
关键词：
D O I：
10.1097/00005373-199812000-00021
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The National Acute Spinal Cord Injury Study (NASCIS) 2 and 3 trials are often cited as evidence that high-dose methylprednisolone is an efficacious intervention in the management of acute spinal cord injury. Neither of these studies convincingly demonstrate the benefit of steroids. There are concerns about the statistical analysis, randomization, and clinical end points. Even if the putative gains are statistically valid, the clinical benefits are questionable. Furthermore, the benefits of this intervention may not warrant the possible risks. This paper comments on these two clinical trials.
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页码：1088 / 1093
页数：6
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