Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats

被引:24
作者
Gamiz, Fernando [1 ]
Gallo, Milagros [1 ]
机构
[1] Univ Granada, Ctr Biomed Res CIBM, Inst Neurosci, Dept Expt Psychol & Physiol Behaviour, E-18071 Granada, Spain
关键词
KINASE-M-ZETA; LONG-TERM-MEMORY; PKM-ZETA; BASOLATERAL AMYGDALA; MAINTENANCE; LESIONS; INACTIVATION; RETRIEVAL; INHIBITOR; MECHANISM;
D O I
10.1101/lm.2253311
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have investigated the effect of protein kinase Mzeta (PKM zeta) inhibition in the basolateral amygdala (BLA) upon the retention of a nonspatial learned active avoidance response and conditioned taste-aversion (CTA) acquisition in rats. ZIP (10 nmol/mu L) injected into the BLA 24 h after training impaired retention of a learned avoidance-jumping response assessed 7 d later when compared with control groups injected with scrambled-ZIP. Nevertheless, a retraining session applied 24 h later indicated no differences between the groups. Additionally, a similar ZIP injection into the BLA during the conditioned stimulus-unconditioned stimulus (CS-US) interval attenuated CTA acquisition. These findings support the BLA PKMz role in various forms of memory.
引用
收藏
页码:529 / 533
页数:5
相关论文
共 43 条
[1]   Effects of central and basolateral amygdala lesions on conditioned taste aversion and latent inhibition [J].
Andre, Justin St. ;
Reilly, Steve .
BEHAVIORAL NEUROSCIENCE, 2007, 121 (01) :90-99
[2]   Visualizing stimulus convergence in amygdala neurons during associative learning [J].
Barot, Sabiha K. ;
Kyono, Yasuhiro ;
Clark, Emily W. ;
Bernstein, Ilene L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (52) :20959-20963
[3]   ONE BOTTLE TOO MANY - METHOD OF TESTING DETERMINES THE DETECTION OF OVERSHADOWING AND RETENTION OF TASTE-AVERSIONS [J].
BATSELL, WR ;
BEST, MR .
ANIMAL LEARNING & BEHAVIOR, 1993, 21 (02) :154-158
[4]   Molecular mechanisms of taste-recognition memory [J].
Bermúdez-Rattoni, F .
NATURE REVIEWS NEUROSCIENCE, 2004, 5 (03) :209-217
[5]  
Bures J., 1998, CONDITIONED TASTE AV
[6]   VERTICAL JUMPING AND SIGNALED AVOIDANCE [J].
CANDIDO, A ;
MALDONADO, A ;
VILA, J .
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR, 1988, 50 (02) :273-276
[7]   Safety signals from avoidance learning but not from yoked classical conditioning training pass both summation and retardation tests for inhibition [J].
Cándido, A ;
González, F ;
de Brugada, I .
BEHAVIOURAL PROCESSES, 2004, 66 (02) :153-160
[8]   EFFECTS OF DURATION OF FEEDBACK ON SIGNALED AVOIDANCE [J].
CANDIDO, A ;
MALDONADO, A ;
VILA, J .
ANIMAL LEARNING & BEHAVIOR, 1991, 19 (01) :81-87
[9]   The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in rats [J].
Choi, June-Seek ;
Cain, Christopher K. ;
LeDoux, Joseph E. .
LEARNING & MEMORY, 2010, 17 (03) :139-147
[10]   Mapping the brain pathways of traumatic memory: Inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats [J].
Cohen, Hagit ;
Kozlovsky, Nitsan ;
Matar, Michael A. ;
Kaplan, Zeev ;
Zohar, Joseph .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2010, 20 (04) :253-271