Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus

被引：2

作者：

Wolf, Jennifer J. ^{[1
,2
]}

Saba, Julie D. ^{[3
]}

Hahm, Bumsuk ^{[1
,2
]}

机构：

[1] Univ Missouri, Dept Surg, 1 Hosp Dr, Columbia, MO 65212 USA

[2] Univ Missouri, Dept Mol Microbiol & Immunol, 1 Hosp Dr, Columbia, MO 65212 USA

[3] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA

来源：

DNA AND CELL BIOLOGY | 2022年 / 41卷 / 04期

关键词：

sphingosine-1-phosphate lyase; type I interferon; viral immune evasion; influenza A virus; virus-host interactions; NS1; PROTEIN; SPHINGOSINE-1-PHOSPHATE LYASE; I INTERFERON; RNA-BINDING; DEFICIENCY; DEGRADATION; INHIBITION; METABOLISM; ACTIVATION; MUTATIONS;

D O I：

10.1089/dna.2022.0071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingosine 1-phosphate lyase (SPL) is a critical component of sphingosine 1-phosphate (S1P) metabolism. SPL has been associated with several crucial cellular functions due to its role in S1P metabolism, but its role in viral infections is poorly understood. Studies show that SPL has an antiviral function against influenza A virus (IAV) by interacting with IKKe, promoting the type I interferon (IFN) innate immune response to IAV infection. However, a more recent study has revealed that IAV NS1 protein hampers this by triggering ubiquitination and subsequent degradation of SPL, which reduces the type I IFN innate immune response. In this study, we describe SPL, the type I IFN response, and known interactions between SPL and IAV.

引用

页码：331 / 335

页数：5

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