Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate

被引：5

作者：

Yang, HT

Bergsteinsdottir, K

Wernhoff, P

Linington, C

Pettersson, U

Holmdahl, R ^{[1
]}

机构：

[1] Lund Univ, Sect Inflammat Res, S-22362 Lund, Sweden

[2] Univ Uppsala, Rudbeck Lab, Dept Genet & Pathol, Med Genet Sect, S-75185 Uppsala, Sweden

[3] Max Planck Inst Neurobiol, Dept Neuroimmunol, Martinsried, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 117卷 / 1-2期

关键词：

experimental allergic encephalomyelitis autoantibodies; myelin basic protein; myelin oligodendrocyte glycoprotein; genetic analysis; major histocompatibility complex;

D O I：

10.1016/S0165-5728(01)00320-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. ln contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 29

页数：9

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