Antithyroid drug-induced fetal goitrous hypothyroidism

被引：34

作者：

Bliddal, Sofie ^{[1
]}

Rasmussen, Ase Krogh ^{[1
]}

Sundberg, Karin ^{[2
]}

Brocks, Vibeke ^{[2
]}

Feldt-Rasmussen, Ulla ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Dept Med Endocrinol, DK-2100 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Dept Fetal Med & Ultrasound, DK-2100 Copenhagen, Denmark

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2011年 / 7卷 / 07期

关键词：

THYROID-STIMULATING HORMONE; IN-UTERO TREATMENT; FREE-THYROXINE MEASUREMENTS; MATERNAL GRAVES-DISEASE; EARLY-PREGNANCY; NEONATAL HYPERTHYROIDISM; ANTENATAL DIAGNOSIS; PLACENTAL-TRANSFER; CHILDREN BORN; RISK-FACTOR;

D O I：

10.1038/nrendo.2011.34

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T-4 are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T-4 levels.

引用

页码：396 / 406

页数：11

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