New Insights into the Molecular Distinction of Dysplastic Nevi and Common Melanocytic Nevi-Highlighting the Keratinocyte-Melanocyte Relationship

被引：4

作者：

Eliades, Philip ^{[1
,2
,3
]}

Tsao, Hensin ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Dermatol, Boston, MA USA

[3] Tufts Univ, Sch Med, Boston, MA 02111 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2016年 / 136卷 / 10期

关键词：

LESIONS; SENESCENCE; PATHWAYS;

D O I：

10.1016/j.jid.2016.01.008

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mitsui et al. approach the problem of differentiating dysplastic nevi from common melanocytic nevi through a molecular lens. Whereas most of the literature on this topic shines the spotlight toward melanocytes, the focus of this paper is shifted to the tumor microenvironment. Using microarrays, reverse transcriptase-PCR, and immunohistochemistry, their results emphasize the role of keratinocyte dysplasia within dysplastic nevi.

引用

页码：1933 / 1935

页数：3