The beneficial role of companion animals in translational pain research

被引：11

作者：

Lascelles, B. Duncan X. ^{[1
,2
,3
,4
]}

Brown, Dottie C. ^{[5
]}

Conzemius, Michael G. ^{[6
]}

Gill, Marie ^{[7
]}

Oshinsky, Michael L. ^{[7
]}

Sharkey, Michelle ^{[8
]}

机构：

[1] North Carolina State Univ, Coll Vet Med, Dept Clin Sci, Translat Res Pain, Raleigh, NC 27695 USA

[2] North Carolina State Univ, Coll Vet Med, Comparat Pain Res & Educ Ctr, Raleigh, NC 27695 USA

[3] UNC Sch Med, Thurston Arthrit Ctr, Chapel Hill, NC 27599 USA

[4] Duke Univ, Ctr Translat Pain Res, Dept Anesthesiol, Durham, NC 27708 USA

[5] Elanco Anim Hlth, Global Efficacy & Model Dev, Greenfield, IN USA

[6] Univ Minnesota, Coll Vet Med, Clin Invest Ctr, St Paul, MN USA

[7] NINDS, NIH, Bethesda, MD 20892 USA

[8] US FDA, Ctr Vet Med, Rockville, MD 20855 USA

来源：

FRONTIERS IN PAIN RESEARCH | 2022年 / 3卷

关键词：

canine; model; pain; translational; drug develoment process; KING-CHARLES SPANIELS; CHIARI-LIKE MALFORMATION; TOTAL HIP-REPLACEMENT; SUBSTANCE P-SAPORIN; PHYSICAL-ACTIVITY; CLINICAL-TRIALS; INTRATHECAL RESINIFERATOXIN; RECEPTOR ANTAGONIST; CONSCIOUS DOGS; GAIT ANALYSIS;

D O I：

10.3389/fpain.2022.1002204

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The use of spontaneous painful disease in companion pet animals has been highlighted as one of the changes that could be made to help improve translation of basic science to new therapeutics, acting as a bridge between preclinical and clinical studies, with the goal of accelerating the approval of new therapeutics. This review focuses on the utility of companion pet dogs for translational research by reviewing what outcome measures can be measured, and importantly, the relevance of these outcome measures to human translational research. It also details the practical considerations involved in incorporating companion dogs into human therapeutic development.

引用

页数：13

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