Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin

被引：20

作者：

Gao, Juan ^{[1
]}

Su, Gang ^{[2
]}

Liu, Jifei ^{[1
]}

Zhang, Jiajia ^{[1
]}

Zhou, Juanping ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Tian, Ye ^{[1
]}

Zhang, Zhenchang ^{[1
]}

机构：

[1] Lanzhou Univ, Dept Neurol, Hosp 2, Lanzhou 730030, Gansu, Peoples R China

[2] Lanzhou Univ, Sch Basic Med Sci, Inst Genet, Lanzhou 730000, Gansu, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2020年 / 70卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Melatonin; Microglia; Inflammation; Oxidative stress; Apoptosis; SIGNALING PATHWAY; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES; BV2; MICROGLIA; BRAIN; PROTECTS; INJURY; CELLS; MAPK; RATS;

D O I：

10.1007/s12031-020-01531-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the innate immune cells that permanently reside in the central nervous system (CNS), microglia play an increasingly important role in maintaining brain function. Normally, microglia act as resting phenotype, which can be activated by various types of stimuli and release a variety of inflammatory mediators. Melatonin is an endogenous rhythmic hormone secreted principally by the pineal gland. Increasing evidence suggests that melatonin can detoxify reactive oxygen species (ROS) and prevent microglia from over-activation. This review summarizes the mechanisms of melatonin in inhibiting excessive activation of microglia and demonstrates the feasibility of melatonin in the treatment of diseases related to microglial over-activation.

引用

页码：1229 / 1236

页数：8

共 86 条

[1] Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain [J].

Ali, Tahir ;

Rehman, Shafiq Ur ;

Shah, Fawad Ali ;

Kim, Myeong Ok .

JOURNAL OF NEUROINFLAMMATION, 2018, 15

[2] Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells [J].

Amati, Anca-Laura ;

Zakrzewicz, Anna ;

Siebers, Kathrin ;

Wilker, Sigrid ;

Heldmann, Sarah ;

Zakrzewicz, Dariusz ;

Hecker, Andreas ;

McIntosh, J. Michael ;

Padberg, Winfried ;

Grau, Veronika .

MEDIATORS OF INFLAMMATION, 2017, 2017

[3]

ANO Y, 2020, CURR ALZHEIMER RES

[4] Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway [J].

Arioz, Burak, I ;

Tastan, Bora ;

Tarakcioglu, Emre ;

Tufekci, Kemal Ugur ;

Olcum, Melis ;

Ersoy, Nevin ;

Bagriyanik, Alper ;

Genc, Kursad ;

Genc, Sermin .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[5] Chemokines in the brain: neuroimmunology and beyond [J].

Biber, K ;

Zuurman, MW ;

Dijkstra, IM ;

Boddeke, HWGM .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (01) :63-68

[6] Caspase signalling controls microglia activation and neurotoxicity [J].

Burguillos, Miguel A. ;

Deierborg, Tomas ;

Kavanagh, Edel ;

Persson, Annette ;

Hajji, Nabil ;

Garcia-Quintanilla, Albert ;

Cano, Josefina ;

Brundin, Patrik ;

Englund, Elisabet ;

Venero, Jose L. ;

Joseph, Bertrand .

NATURE, 2011, 472 (7343) :319-U214

[7] Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling [J].

Cao, Qiong ;

Karthikeyan, Aparna ;

Dheen, S. Thameem ;

Kaur, Charanjit ;

Ling, Eng-Ang .

PLOS ONE, 2017, 12 (10)

[8] Role of Melatonin in the Inflammatory Process and its Therapeutic Potential [J].

Carrascal, Livia ;

Nunez-Abades, Pedro ;

Ayala, Antonio ;

Cano, Mercedes .

CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (14) :1563-1588

[9] Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes [J].

Chaturantabut, Saireudee ;

Shwartz, Arkadi ;

Evason, Kimberley J. ;

Cox, Andrew G. ;

Labella, Kyle ;

Schepers, Arnout G. ;

Yang, Song ;

Acuna, Mariana ;

Houvras, Yariv ;

Mancio-Silva, Liliana ;

Romano, Shannon ;

Gorelick, Daniel A. ;

Cohen, David E. ;

Zon, Leonard, I ;

Bhatia, Sangeeta N. ;

North, Trista E. ;

Goessling, Wolfram .

GASTROENTEROLOGY, 2019, 156 (06) :1788-+

[10] Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia [J].

Cheng, Jinbo ;

Liao, Yajin ;

Xiao, Lei ;

Wu, Rong ;

Zhao, Siqi ;

Chen, Hong ;

Hou, Baidong ;

Zhang, Xia ;

Liang, Chengyu ;

Xu, Yun ;

Yuan, Zengqiang .

CELL DEATH AND DIFFERENTIATION, 2017, 24 (02) :276-287

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