Vesicles of yeast cell wall-sitagliptin to alleviate neuroinflammation in Alzheimer's disease

被引：10

作者：

Mozafari, Negin ^{[1
,2
]}

Dehshahri, Ali ^{[3
,4
]}

Ashrafi, Hajar ^{[2
]}

Mohammadi-Samani, Soliman ^{[2
,4
]}

Shahbazi, Mohammad-Ali ^{[5
,6
]}

Heidari, Reza ^{[4
]}

Azarpira, Negar ^{[7
]}

Azadi, Amir ^{[2
,4
]}

机构：

[1] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[2] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut, Shiraz, Iran

[3] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Shiraz, Iran

[4] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[6] Zanjan Univ Med Sci, Zanjan Pharmaceut Nanotechnol Res Ctr ZPNRC, Zanjan 4513956184, Iran

[7] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2022年 / 44卷

关键词：

Alzheimer's disease; Cell-based drug delivery; Microglia; Neuroinflammation; Sitagliptin; METHOTREXATE-LOADED CHITOSAN; DIPEPTIDYL PEPTIDASE-4; BRAIN; NANOPARTICLES; STIMULATION; DELIVERY; MEMORY;

D O I：

10.1016/j.nano.2022.102575

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A cell-based drug delivery system based on yeast-cell wall loaded with sitagliptin, a drug with an anti-inflammatory effect, was developed to control neuroinflammation associated with Alzheimer's disease. The optimized nanoparticles had a spherical shape with a negative surface charge, and were shown to be less toxic than the carrier and sitagliptin. Moreover, the nanoparticles caused anti-inflammatory effects against tumor necrosis factor-alpha in mice model of neuroinflammation. The pharmacokinetics study showed the brain concentration of drug in the nanoparticles group was much higher than in the control group. To evaluate the effect of P-glycoprotein on brain entry of sitagliptin, the experiment was repeated with verapamil, as a P-glycoprotein inhibitor. Brain concentration of the nanoparticles group remained approximately unchanged, proving the "Trojan Horse" effect of the developed nanocarriers. The results are promising for using yeast-cell wall as a carrier for targeted delivery to immune cells for the management of inflammation.(c) 2022 Elsevier Inc. All rights reserved.

引用

页数：12

共 47 条

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