Evaluation of Gut Microbial Changes in Human and Murine Models in Response to Antibiotics

被引：1

作者：

Kumar, S. ^{[1
]}

Perumal, N. ^{[2
]}

Raj, V. S. ^{[3
]}

机构：

[1] Minist Hlth & Family Welf, Natl Inst Biolog, Noida 201303, Uttar Pradesh, India

[2] Natl Inst Immunol, New Delhi 110067, India

[3] SRM Univ, Ctr Drug Design Discovery & Dev C4D, Sonepat 131023, Haryana, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2021年 / 83卷 / 06期

关键词：

Antibiotics; gut ecology; murine microbiota; human microbiome; INTESTINAL MICROBIOTA; IMPACT; NITROFURANTOIN; COLONIZATION; MICROFLORA; RESISTANCE; RECOVERY; THERAPY; TRACT;

D O I：

10.36468/pharmaceutical-sciences.887

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Widespread usage of antibiotics disrupted the host bacterial mutualism in the human intestine. The antibiotic alterations can drive the functionality of the gut microbiota towards a state similar to those observed under various disease states in humans. The emergence of antibiotic-resistant bacteria further spurred the development of the antimicrobial crisis all over the world. Antibiotics have an essential role in treating various diseases. To understand the intricate relationship between antibiotics and human gut microbiota, the basic understanding of the microbial signature of gut dysbiosis in human patients and murine models in response to antibiotics treatment is very crucial. Therefore, we examined the effects of most commonly used antibiotics on human and murine gut microbiota, when administered alone or in a combination, under this article.

引用

页码：1308 / +

页数：7

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