Non-invasive in situ identification and band assignments of diazepam, flunitrazepam and methadone hydrochloride with FT-near-infrared spectroscopy

被引：16

作者：

Ali, Hassan Refat H. ^{[1
]}

机构：

[1] Assiut Univ, Dept Pharmaceut Analyt Chem, Fac Pharm, Assiut 71526, Egypt

来源：

FORENSIC SCIENCE INTERNATIONAL | 2011年 / 206卷 / 1-3期

关键词：

Diazepam; Flunitrazepam; Methadone; In situ; NIR spectroscopy; Drugs; CONTENT UNIFORMITY; PHARMACEUTICAL TABLETS; TRANSMISSION; PRINCIPLES; EXCIPIENTS; HARDNESS;

D O I：

10.1016/j.forsciint.2010.06.029

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Near-infrared spectroscopy (NIR) has evolved into an important rapid, direct and non-invasive technique in drugs analysis. In this study, the suitability of NIR spectroscopy to identify two benzodiazepine derivatives, diazepam and flunitrazepam, and a synthetic opiate, methadone hydrochloride, inside USP vials and probe the solid-state form of diazepam presents in tablets has been explored. The results show the potential of NIR spectroscopy for rapid, in situ and non-destructive identification of drugs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：87 / 91

页数：5

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