Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297

被引：9

作者：

Xu, Liancheng ^{[1
]}

Liu, Guodong ^{[1
]}

Chen, Yu ^{[1
]}

Liu, Shan ^{[1
]}

Luo, Weihuan ^{[1
]}

Hu, Pengfei ^{[1
]}

Huang, Changming ^{[1
]}

Ji, Xiang ^{[1
]}

Wang, Shiping ^{[1
]}

Cao, Guanyi ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Suqian Peoples Hosp 1, Suqian 223800, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2022年 / 16卷 / 05期

关键词：

Aspergillus flavipes; natural products; drimane sesquiterpenoids; cytotoxicity;

D O I：

10.25135/rnp.294.2109.2194

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.

引用

页码：488 / 492

页数：5

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