Ga(OTf)3-promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate

被引：6

作者：

Yang, Fengxia ^{[1
,2
]}

An, Weiteng ^{[2
]}

Qian, Zhiwei ^{[2
]}

Yu, Ting ^{[2
]}

Du, Yongli ^{[1
]}

Ma, Lanping ^{[2
]}

Wang, Xin ^{[2
]}

Meng, Tao ^{[2
]}

Shen, Jingkang ^{[2
]}

机构：

[1] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Jinan 250353, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 40期

基金：

中国国家自然科学基金;

关键词：

BLACKBURN-BIENAYME REACTION; COMBINATORIAL SYNTHESIS; ANTIVIRAL ACTIVITY; HIGH-AFFINITY; ACID-ESTERS; DERIVATIVES; INHIBITORS; BINDING; AGENTS; EQUIVALENTS;

D O I：

10.1039/c5ra02809d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient route to the synthesis of 3-amino-2-ethoxycarbonyl imidazo[1,2-a]pyridine derivatives starting from ethyl alpha-benzotriazolyl-alpha-morpholinoacetate has been developed. By the reactions between primary heterocyclic amidines and isocyanides catalyzed by Ga(OTf)(3), target compounds were obtained in moderate to good yields. This in turn will set the stage for the wide application of this useful reaction for the synthesis of 3-amino-2-carbonylimidazo[1,2-a]pyridines based on imidazo[1,2-a]pyridine privileged structures.

引用

收藏

页码：32015 / 32019

页数：5

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