Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic

被引：131

作者：

Grover, Amit ^{[1
]}

Sanseviero, Emilio ^{[2
]}

Timosenko, Elina ^{[1
]}

Gabrilovich, Dmitry, I ^{[2
]}

机构：

[1] AstraZeneca, R&D, Early Oncol, ICC, Cambridge, England

[2] AstraZeneca, ICC, Early Oncol R&D, Gaithersburg, MD 20878 USA

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 11期

关键词：

TRANS-RETINOIC ACID; IMMUNE-RESPONSE; BREAST-CANCER; T-CELLS; INHIBITION; MDSC; DIFFERENTIATION; ACTIVATION; IMPROVES; ANTIGEN;

D O I：

10.1158/2159-8290.CD-21-0764

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in cancer. They represent a relatively stable form of pathologic activation of neutrophils and monocytes and are characterized by distinct transcriptional, biochemical, functional, and phenotypical features. The close association of MDSCs with clinical outcomes in cancer suggests that these cells can be an attractive target for therapeutic intervention. However, the complex nature of MDSC biology represents a substantial challenge for the development of selective therapies. Here, we discuss the mechanisms regulating MDSC development and fate and recent research advances that have demonstrated opportunities for therapeutic regulation of these cells. Significance: MDSCs are attractive therapeutic targets because of their close association with negative clinical outcomes in cancer and established biology as potent immunosuppressive cells. However, the complex nature of MDSC biology presents a substantial challenge for therapeutic targeting. In this review, we discuss those challenges and possible solutions.

引用

页码：2693 / 2706

页数：14

共 112 条

[1] Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway [J].

Alicea-Torres, Kevin ;

Sanseviero, Emilio ;

Gui, Jun ;

Chen, Jinyun ;

Veglia, Filippo ;

Yu, Qiujin ;

Donthireddy, Laxminarasimha ;

Kossenkov, Andrew ;

Lin, Cindy ;

Fu, Shuyu ;

Mulligan, Charles ;

Nam, Brian ;

Masters, Gregory ;

Denstman, Fred ;

Bennett, Joseph ;

Hockstein, Neil ;

Rynda-Apple, Agnieszka ;

Nefedova, Yulia ;

Fuchs, Serge Y. ;

Gabrilovich, Dmitry, I .

NATURE COMMUNICATIONS, 2021, 12 (01)

[2] Co-option of Neutrophil Fates by Tissue Environments [J].

Ballesteros, Ivan ;

Rubio-Ponce, Andrea ;

Genua, Marco ;

Lusito, Eleonora ;

Kwok, Immanuel ;

Fernandez-Calvo, Gabriel ;

Khoyratty, Tariq E. ;

van Grinsven, Erinke ;

Gonzalez-Hernandez, Sara ;

Angel Nicolas-Avila, Jose ;

Vicanolo, Tommaso ;

Maccataio, Antonio ;

Benguria, Alberto ;

Li, Jackson LiangYao ;

Adrover, Jose M. ;

Aroca-Crevillen, Alejandra ;

Quintana, Juan A. ;

Martin-Salamanca, Sandra ;

Mayo, Francisco ;

Ascher, Stefanie ;

Barbiera, Giulia ;

Soehnlein, Oliver ;

Gunzer, Matthias ;

Ginhoux, Florent ;

Sanchez-Cabo, Fatima ;

Nistal-Villan, Estanislao ;

Schulz, Christian ;

Dopazo, Ana ;

Reinhardt, Christoph ;

Udalova, Irina A. ;

Ng, Lai Guan ;

Ostuni, Renato ;

Hidalgo, Andres .

CELL, 2020, 183 (05) :1282-+

[3] Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth [J].

Bruchard, Melanie ;

Mignot, Gregoire ;

Derangere, Valentin ;

Chalmin, Fanny ;

Chevriaux, Angelique ;

Vegran, Frederique ;

Boireau, Wilfrid ;

Simon, Benoit ;

Ryffel, Bernhard ;

Connat, Jean Louis ;

Kanellopoulos, Jean ;

Martin, Francois ;

Rebe, Cedric ;

Apetoh, Lionel ;

Ghiringhelli, Francois .

NATURE MEDICINE, 2013, 19 (01) :57-64

[4] Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells [J].

Chalmin, Fanny ;

Ladoire, Sylvain ;

Mignot, Gregoire ;

Vincent, Julie ;

Bruchard, Melanie ;

Remy-Martin, Jean-Paul ;

Boireau, Wilfrid ;

Rouleau, Alain ;

Simon, Benoit ;

Lanneau, David ;

De Thonel, Aurelie ;

Multhoff, Gabriele ;

Hamman, Arlette ;

Martin, Francois ;

Chauffert, Bruno ;

Solary, Eric ;

Zitvogel, Laurence ;

Garrido, Carmen ;

Ryffel, Bernhard ;

Borg, Christophe ;

Apetoh, Lionel ;

Rebe, Cedric ;

Ghiringhelli, Francois .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :457-471

[5] A Phase Ib and II clinical trial investigating the efficacy of nitric oxide deprivation and docetaxel in triple negative breast cancer [J].

Chung, Andrew W. ;

Ensor, Joe E. ;

Darcourt, Jorge ;

Belcheva, Anna ;

Patel, Tejal ;

Chang, Jenny C. ;

Niravath, Polly A. .

CANCER RESEARCH, 2019, 79 (13)

[6] Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients [J].

Condamine, Thomas ;

Dominguez, George A. ;

Youn, Je-In ;

Kossenkov, Andrew V. ;

Mony, Sridevi ;

Alicea-Torres, Kevin ;

Tcyganov, Evgenii ;

Hashimoto, Ayumi ;

Nefedova, Yulia ;

Lin, Cindy ;

Partlova, Simona ;

Garfall, Alfred ;

Vogl, Dan T. ;

Xu, Xiaowei ;

Knight, Stella C. ;

Malietzis, George ;

Lee, Gui Han ;

Eruslanov, Evgeniy ;

Albelda, Steven M. ;

Wang, Xianwei ;

Mehta, Jawahar L. ;

Bewtra, Meenakshi ;

Rustgi, Anil ;

Hockstein, Neil ;

Witt, Robert ;

Masters, Gregory ;

Nam, Brian ;

Smirnov, Denis ;

Sepulveda, Manuel A. ;

Gabrilovich, Dmitry I. .

SCIENCE IMMUNOLOGY, 2016, 1 (02)

[7] Transcriptional regulation of myeloid-derived suppressor cells [J].

Condamine, Thomas ;

Mastio, Jerome ;

Gabrilovich, Dmitry I. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (06) :913-922

[8] ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis [J].

Condamine, Thomas ;

Kumar, Vinit ;

Ramachandran, Indu R. ;

Youn, Je-In ;

Celis, Esteban ;

Finnberg, Niklas ;

El-Deiry, Wafik S. ;

Winograd, Rafael ;

Vonderheide, Robert H. ;

English, Nickolas R. ;

Knight, Stella C. ;

Yagita, Hideo ;

McCaffrey, Judith C. ;

Antonia, Scott ;

Hockstein, Neil ;

Witt, Robert ;

Masters, Gregory ;

Bauer, Thomas ;

Gabrilovich, Dmitry I. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (06) :2626-2639

[9] HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment [J].

Corzo, Cesar A. ;

Condamine, Thomas ;

Lu, Lily ;

Cotter, Matthew J. ;

Youn, Je-In ;

Cheng, Pingyan ;

Cho, Hyun-Il ;

Celis, Esteban ;

Quiceno, David G. ;

Padhya, Tapan ;

McCaffrey, Thomas V. ;

McCaffrey, Judith C. ;

Gabrilovich, Dmitry I. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (11) :2439-2453

[10] Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer [J].

Davila-Gonzalez, Daniel ;

Choi, Dong Soon ;

Rosato, Roberto R. ;

Granados-Principal, Sergio M. ;

Kuhn, John G. ;

Li, Wen-Feng ;

Qian, Wei ;

Chen, Wen ;

Kozielski, Anthony J. ;

Wong, Helen ;

Dave, Bhuvanesh ;

Chang, Jenny C. .

CLINICAL CANCER RESEARCH, 2018, 24 (05) :1152-1162

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