Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata

被引：26

作者：

Alam, N

Bae, BH

Hong, J

Lee, CO

Shin, BA

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Basic Sci Inst, Mass Spectrometry Grp, Taejon, South Korea

[3] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea

[4] Chonnam Natl Univ, Res Inst Med Sci, Kwangju, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期

关键词：

D O I：

10.1021/np0005210

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A known (1) and four new (2-5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2 '. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.

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页码：533 / 535

页数：3

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