Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents

被引：19

作者：

Liu, Mengmeng ^{[1
]}

Wang, Shui ^{[1
]}

Qu, Chao ^{[2
]}

Zhang, Zhichao ^{[1
]}

Qu, Yixin ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Beijing Key Lab Membrane Sci & Technol, Coll Chem Engn, Beijing 100029, Peoples R China

[2] Beidou Aerosp Satellite Applicat Technol Grp Co L, Beijing 100070, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2020年 / 65卷 / 04期

关键词：

MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; MIXING PROPERTIES; DRUG BEZAFIBRATE; MONOSOLVENTS; MIXTURES; WATER;

D O I：

10.1021/acs.jced.0c00025

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

In this work, the solubility of bezafibrate in 16 pure solvents including 9 alcohols (methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, 1-pentanol, and iso-pentanol), 4 alkyl acetate (ethyl acetate, n-propyl acetate, n-butyl acetate, and methyl propionate), 2 ketones (methyl ethyl ketone and cyclohexanone) and one nitrile (acetonitrile) and in binary mixed solvents (methanol + acetonitrile) at temperature of 283.15-323.15 K was determined. The solubility of bezafibrate in pure solvents was simulated using modified Apelblat, Van't Hoff, Wilson, and NRTL model. That in binary mixed solvents was simulated using the modified Apelblat and Apelblat-Jouyban-Acree model. The thermodynamic mixing properties (Delta(mix)G, Delta H-mix, Delta S-mix, gamma(infinity)(1), and H-1(E),infinity) of the bezafibrate-pure solvent systems were evaluated based on the solubility data and Wilson model.

引用

页码：2156 / 2169

页数：14

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