Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination

被引：7

作者：

Costopoulos, Myrto ^{[1
,2
,3
]}

Kim, Rathana ^{[1
]}

Choquet, Sylvain ^{[4
]}

Maloum, Karim ^{[1
]}

Houillier, Caroline ^{[5
]}

Algrin, Caroline ^{[4
]}

Settegrana, Catherine ^{[1
]}

Villemonteix, Juliette ^{[1
]}

Brissard, Martine ^{[1
]}

Quiney, Claire ^{[1
]}

Bernard, Sophie ^{[6
,7
]}

Davi, Frederic ^{[1
,2
,3
]}

Thieblemont, Catherine ^{[6
,7
]}

Hoang-Xuan, Khe ^{[2
]}

Leblond, Veronique ^{[2
,4
]}

Merle-Beral, Helene ^{[1
,2
,3
]}

Le Garff-Tavernier, Magali ^{[1
,3
]}

机构：

[1] Hop La Pitie Salpetriere, Dept Biol Hematol, 47-83 Blvd Hop, F-75013 Paris, France

[2] Sorbonne Univ, UPMC, Paris, France

[3] Ctr Rech Cordeliers Cell Death & Drug Resistance, Paris, France

[4] Hop La Pitie Salpetriere, Dept Clin Hematol, Paris, France

[5] Hop La Pitie Salpetriere, Dept Neurooncol, Paris, France

[6] Diderot 7 Univ, St Louis Hosp, AP HP, Hematooncol Dept, Paris, France

[7] Diderot 7 Univ, Paris Cite Sorbonne, Paris, France

来源：

SEMINARS IN HEMATOLOGY | 2018年 / 55卷 / 04期

关键词：

CNS LYMPHOMA; DIAGNOSIS; INVOLVEMENT; LEUKEMIA; DISEASE;

D O I：

10.1053/j.seminhematol.2017.06.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another "hidden" lymphoma such as primary CNS lymphoma (PCNSL). (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：179 / 181

页数：3

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