Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides

被引：108

作者：

Spicer, Christopher D. ^{[1
]}

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

NONNATURAL AMINO-ACIDS; MALTOSE-BINDING PROTEIN; CROSS-METATHESIS; IN-VIVO; CHEMISTRY; BIOLOGY; FUNCTIONALITY; PHENYLALANINE; STRATEGIES; PEPTIDES;

D O I：

10.1039/c0cc04970k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger.

引用

页码：1698 / 1700

页数：3

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