Current Status of Long Non-Coding RNAs in Human Breast Cancer

被引：62

作者：

Cerk, Stefanie ^{[1
,2
]}

Schwarzenbacher, Daniela ^{[1
,2
]}

Adiprasito, Jan Basri ^{[1
,2
]}

Stotz, Michael ^{[1
,2
]}

Hutterer, Georg C. ^{[3
]}

Gerger, Armin ^{[1
]}

Ling, Hui ^{[4
]}

Calin, George Adrian ^{[4
]}

Pichler, Martin ^{[1
,2
,4
]}

机构：

[1] Med Univ Graz, Div Oncol, Dept Internal Med, A-8026 Graz, Austria

[2] Med Univ Graz, Res Unit Noncoding RNA & Genome Editing Canc, A-8036 Graz, Austria

[3] Med Univ Graz, Dept Urol, A-8036 Graz, Austria

[4] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77054 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 09期

关键词：

breast cancercarcinoma; long non-coding RNA; oncogene; tumor suppressor; PROMOTES CELL-PROLIFERATION; PROTEIN-CODING RNA; POOR-PROGNOSIS; H19; GENE; COLORECTAL-CANCER; GASTRIC-CANCER; IMPRINTED H19; LUNG-CANCER; C-MYC; MOLECULAR-MECHANISMS;

D O I：

10.3390/ijms17091485

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer represents a major health burden in Europe and North America, as recently published data report breast cancer as the second leading cause of cancer related death in women worldwide. Breast cancer is regarded as a highly heterogeneous disease in terms of clinical course and biological behavior and can be divided into several molecular subtypes, with different prognosis and treatment responses. The discovery of numerous non-coding RNAs has dramatically changed our understanding of cell biology, especially the pathophysiology of cancer. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts >200 nucleotides in length. Several studies have demonstrated their role as key regulators of gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including breast cancer. lncRNAs are involved in cancer initiation, progression, and metastases. In this review, we summarize the recent literature to highlight the current status of this class of long non-coding lncRNAs in breast cancer.

引用

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