Lanthanide-doped calcium phosphate nanoparticles with high internal crystallinity and with a shell of DNA as fluorescent probes in cell experiments

被引：117

作者：

Mondejar, Sussette Padilla ^{[1
]}

Kovtun, Anna ^{[1
]}

Epple, Matthias ^{[1
]}

机构：

[1] Univ Duisburg Essen, Inst Inorgan Chem, D-45117 Essen, Germany

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2007年 / 17卷 / 39期

关键词：

D O I：

10.1039/b708258d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Calcium phosphate nanoparticles were prepared by precipitation and stabilized as colloids by coating with DNA. They were doped with europium or terbium during this precipitation (about 2.5 wt%) and showed good fluorescence in the visible part of the spectrum. The fluorescence efficiency depended strongly on the internal crystallinity, i.e. amorphous nanoparticles of the same composition showed much weaker fluorescence. These particles are biocompatible and are easily taken up by cells (T-HUVEC), i.e. they can be used as fluorescing markers. Different colours can be realized by doping with different lanthanides.

引用

页码：4153 / 4159

页数：7

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