In vitro drug release mechanism and drug loading studies of cubic phase gels

被引：114
作者：
Lara, MG
Bentley, MVLB
Collett, JH
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
[2] Univ Ribeirao Preto, Curso Ciencias Farmaceut, Ribeirao Preto, SP, Brazil
[3] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester, Lancs, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 293卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
glyceryl monooleate; drug delivery systems; cubic phase; swelling studies;
D O I：
10.1016/j.ijpharm.2005.01.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glyceryl monooleate/water cubic phase systems were investigated as drug delivery systems, using salicylic acid as a model drug. The liquid crystalline phases formed by the glyceryl monooleate (GMO)/water systems were characterized by polarizing microscopy. In vitro drug release studies were performed and the influences of initial water content, swelling and drug loading on the drug release properties were evaluated. Water uptake followed second-order swelling kinetics. In vitro release profiles showed Fickian diffusion control and were independent on the initial water content and drug loading, suggesting GMO cubic phase gels suitability for use as drug delivery system. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：241 / 250
页数：10
相关论文
共 35 条
[1]   Drug compatibility with the sponge phases formed in monoolein, water, and propylene glycol or poly(ethylene glycol) [J].
Alfons, K ;
Engstrom, S .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (12) :1527-1530
[2]   Kinetics and mechanism of release from glyceryl monostearate-based implants: Evaluation of release in a gel simulating in vivo implantation [J].
Allababidi, S ;
Shah, JC .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (06) :738-744
[3]   Effects of electrostatic interaction on the phase stability and structures of cubic phases of monoolein/oleic acid mixture membranes [J].
Aota-Nakano, U ;
Li, SJ ;
Yamazaki, M .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1461 (01) :96-102
[4]   THE RELEASE OF DRUGS FROM MONOGLYCERIDE-WATER LIQUID-CRYSTALLINE PHASES [J].
BURROWS, R ;
COLLETT, JH ;
ATTWOOD, D .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, 111 (03) :283-293
[5]   Addition of hydrophilic and lipophilic compounds of biological relevance to the monoolein/water system. I. Phase behavior [J].
Caboi, F ;
Amico, GS ;
Pitzalis, P ;
Monduzzi, M ;
Nylander, T ;
Larsson, K .
CHEMISTRY AND PHYSICS OF LIPIDS, 2001, 109 (01) :47-62
[6]   Drug delivery from a liquid crystalline base across Visking and human stratum corneum [J].
Carr, MG ;
Corish, J ;
Corrigan, OI .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 157 (01) :35-42
[7]   Effect of dissolution media and additives on the drug release from cubic phase delivery systems [J].
Chang, CM ;
Bodmeier, R .
JOURNAL OF CONTROLLED RELEASE, 1997, 46 (03) :215-222
[8]   Low viscosity monoglyceride-based drug delivery systems transforming into a highly viscous cubic phase [J].
Chang, CM ;
Bodmeier, R .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 173 (1-2) :51-60
[9]   Swelling of and drug release from monoglyceride-based drug delivery systems [J].
Chang, CM ;
Bodmeier, R .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (06) :747-752
[10]   Phase behavior of a monoacylglycerol (Myverol 18-99K)/water system [J].
Clogston, J ;
Rathman, J ;
Tomasko, D ;
Walker, H ;
Caffrey, M .
CHEMISTRY AND PHYSICS OF LIPIDS, 2000, 107 (02) :191-220
1234