New synthesis of pentacyclic steroids by stereoselective epoxide ring opening

被引：6

作者：

Ibrahim-Ouali, Malika ^{[1
]}

Khalil, Hamze

机构：

[1] CNRS, UMR 6263, Inst Sci Mol Marseille, F-13397 Marseille, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 52期

关键词：

Pentacyclic steroids; Lactones; Epoxide; 11-OXA STEROIDS; PRODUCTS;

D O I：

10.1016/j.tetlet.2010.10.167

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of pentacyclic steroids has been achieved. Starting from commercially available cholic acid 1, followed by asymmetric epoxidation and by stereoselective epoxide ring opening, employing nucleophilic species, the corresponding products were afforded in good yields. The compounds were being evaluated for their biological activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6948 / 6950

页数：3

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