Interhemispheric synchrony in visual cortex and abnormal postnatal visual experience

被引:11
作者
Foubert, Luc [1 ]
Bennequin, Daniel [2 ]
Thomas, Marie-Annick [1 ]
Droulez, Jacques [1 ]
Milleret, Chantal [1 ]
机构
[1] Coll France, Lab Physiol Percept & Act, UMR CNRS 7152, F-75005 Paris, France
[2] Univ Paris 07, Inst Math, UMR CNRS 7586, F-75005 Paris, France
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2010年 / 15卷
关键词
Corpus callosum; Interhemispheric Connections; Three-Dimensional Reconstruction; Plasticity Of Callosal Terminals; Spike Propagation; Compartmental Model; Synchrony; LATERAL GENICULATE-NUCLEUS; RETINAL GANGLION-CELLS; STIMULUS-DEPENDENT CHANGES; MYELINATED NERVE-FIBER; NASO-TEMPORAL DIVISION; CAT STRIATE CORTEX; CORPUS-CALLOSUM; CORTICOCORTICAL CONNECTIONS; MONOCULAR DEPRIVATION; OSCILLATORY RESPONSES;
D O I
10.2741/3640
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The question of whether neural synchrony may be preserved in adult mammalian visual cortex despite abnormal postnatal visual experience was investigated by combining anatomical and computational approaches. Single callosal axons in visual cortex of early monocularly deprived (MD) adult cats were labeled anterogradely with biocytin in vivo and reconstructed in 3D. Spike propagation was then orthodromically simulated within each of these axons with NEURON (R) software. Data were systematically compared to those previously obtained in normally reared (NR) adult cats with comparable approaches (1-2). The architecture of the callosal axons in MD animals differed significantly from the NR group, with longer branches and first nodes located deeper below the cortex. But, surprisingly, simulation of spike propagation demonstrated that transmission latencies of most spikes remained inferior to 2 ms, like the NR group. These results indicate that synchrony of neural activity may be preserved in adult visual cortex despite abnormal postnatal visual experience. According to the temporal binding hypothesis, this also indicates that the necessary timing for visual perception is present despite anatomical abnormalities in visual cortex.
引用
收藏
页码:681 / 707
页数:27
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