Natural Killer Cell-Based Cancer Immunotherapy: A Review on 10 Years Completed Clinical Trials

被引：68

作者：

Suen, Wade Chun-Wai ^{[1
,2
,3
]}

Lee, Wayne Yuk-Wai ^{[1
,4
]}

Leung, Kam-Tong ^{[5
]}

Pan, Xiao-Hua ^{[2
]}

Li, Gang ^{[1
,4
,6
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Fac Med, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China

[2] Bao An Peoples Hosp, Dept Orthopaed & Traumatol, Shenzhen, Peoples R China

[3] Univ Cambridge, Dept Haematol, Cambridge, England

[4] Chinese Univ Hong Kong, Stem Cells & Regenerat Med Lab, Lui Che Woo Inst Innovat Med, Li Ka Shing Inst Hlth Sci,Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Dept Paediat, Fac Med, Shatin, Hong Kong, Peoples R China

[6] Chinese Univ Hong Kong, Shenzhen Res Inst, CUHK ACC Space Med Ctr Hlth Maintenance Musculosk, Shenzhen, Peoples R China

来源：

CANCER INVESTIGATION | 2018年 / 36卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Natural killer cells; Adoptive cell therapy; Clinical trials; Immunotherapy; Leukaemia; ACUTE MYELOID-LEUKEMIA; REGULATORY T-CELLS; CHRONIC LYMPHOCYTIC-LEUKEMIA; MOUSE LYMPHOID-CELLS; IN-VIVO EXPANSION; PHASE-II TRIAL; NK-CELLS; ANTITUMOR-ACTIVITY; ADOPTIVE TRANSFER; CYTOTOXIC REACTIVITY;

D O I：

10.1080/07357907.2018.1515315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NK cell cancer immunotherapy is an emerging anti-tumour therapeutic strategy that explores NK cell stimulation. In this review, we address strategies developed to circumvent limitations to clinical application of NK cell-based therapies, and comprehensively review the design and results of clinical trials conducted in the past 10 years (2008-2018) to test their therapeutic potential. NK cell-based immunotherapy of solid cancers remains controversial, but merit further detailed investigation.

引用

页码：431 / 457

页数：27

共 191 条

[1] Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components [J].

Alici, Evren ;

Sutlu, Tolga ;

Boejrkstrand, Bo ;

Gilljam, Mari ;

Stellan, Birgitta ;

Nahi, Hareth ;

Quezada, Hernan Concha ;

Gahrton, Goesta ;

Ljunggren, Hans-Gustaf ;

Dilber, M. Sirac .

BLOOD, 2008, 111 (06) :3155-3162

[2]

[Anonymous], IMMUNOL

[3] Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial [J].

Arai, S. ;

Meagher, R. ;

Swearingen, M. ;

Myint, H. ;

Rich, E. ;

Martinson, J. ;

Klingemann, H. .

CYTOTHERAPY, 2008, 10 (06) :625-632

[4] Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein [J].

Bachanova, Veronika ;

Cooley, Sarah ;

Defor, Todd E. ;

Verneris, Michael R. ;

Zhang, Bin ;

McKenna, David H. ;

Curtsinger, Julie ;

Panoskaltsis-Mortari, Angela ;

Lewis, Dixie ;

Hippen, Keli ;

McGlave, Philip ;

Weisdorf, Daniel J. ;

Blazar, Bruce R. ;

Miller, Jeffrey S. .

BLOOD, 2014, 123 (25) :3855-3863

[5]

Bachanova Veronika, 2014, Critical Reviews in Oncogenesis, V19, P133

[6] Allogeneic natural killer cells for refractory lymphoma [J].

Bachanova, Veronika ;

Burns, Linda J. ;

McKenna, David H. ;

Curtsinger, Julie ;

Panoskaltsis-Mortari, Angela ;

Lindgren, Bruce R. ;

Cooley, Sarah ;

Weisdorf, Daniel ;

Miller, Jeffrey S. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2010, 59 (11) :1739-1744

[7] Effect of Donor KIR2DL1 Allelic Polymorphism on the Outcome of Pediatric Allogeneic Hematopoietic Stem-Cell Transplantation [J].

Bari, Rafijul ;

Rujkijyanont, Piya ;

Sullivan, Erin ;

Kang, Guolian ;

Turner, Victoria ;

Gan, Kwan ;

Leung, Wing .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (30) :3782-+

[8] Molecular determinant-based typing of KIR alleles and KIR ligands [J].

Bari, Rafijul ;

Leung, Matthias ;

Turner, Victoria E. ;

Embrey, Christy ;

Rooney, Barbara ;

Holladay, Martha ;

Leung, Wing .

CLINICAL IMMUNOLOGY, 2011, 138 (03) :274-281

[9] Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a Phase I clinical study [J].

Barkholt, L. ;

Alici, E. ;

Conrad, R. ;

Sutlu, T. ;

Gilljam, M. ;

Stellan, B. ;

Christensson, B. ;

Guven, H. ;

Bjorkstrom, N. K. ;

Soderdahl, G. ;

Cederlund, K. ;

Kimby, E. ;

Aschan, J. ;

Ringden, O. ;

Ljunggren, H-G ;

Dilber, M. S. .

IMMUNOTHERAPY, 2009, 1 (05) :753-764

[10] The killer immunoglobulin-like receptor gene cluster: Tuning the genome for defense [J].

Bashirova, Arman A. ;

Martin, Maureen P. ;

McVicar, Daniel W. ;

Carrington, Mary .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :277-300

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