Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine

被引：4

作者：

Seio, K

Negishi, T

Negishi, K

Sekine, M ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Life Sci, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Tokyo Inst Technol, Frontier Collaborat Res Ctr, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[3] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

[4] Okayama Univ, Adv Sci Res Ctr, Okayama 7008530, Japan

[5] Japan Sci & Technol Agcy, CREST, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

LETTERS IN ORGANIC CHEMISTRY | 2005年 / 2卷 / 02期

关键词：

6-O-ethylguanine; degenerated base; mutation; phenoxyacetyl group; depurination; oligodeoxynucleotide synthesis;

D O I：

10.2174/1570178053202982

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The phenoxyacetyl (Pac) group proved to be useful for the synthesis of oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be removed by mild treatment with ammonia, formation of a 2, 4-diaminopurine derivative was avoided. Moreover, the use of the Pac group resulted in significant suppression of the depurination of 6-O-ethyldeoxyguanosine.

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收藏

页码：179 / 183

页数：5

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