Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms

被引:27
作者
Capaccio, P
Ottaviani, F
Cuccarini, V
Ambrosetti, U
Fagnani, E
Bottero, A
Cenzuales, S
Cesana, BM
Pignataro, L
机构
[1] Osped Maggiore, IRCCS, Clin ORL1, I-20100 Milan, Italy
[2] Osped Maggiore, IRCCS, Lab Epidemiol, I-20100 Milan, Italy
[3] Polo Univ Vialba, Ctr Transfus, Azienda Osped L Sacco, Milan, Italy
[4] Polo Univ Vialba, Clin Otorinolaringoiat, Milan, Italy
关键词
MTHFR gene polymorphisms; vascular impairment; sudden hearing loss;
D O I
10.1097/01.GIM.0000157817.92509.45
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose: Sudden hearing loss (SHL) can be caused by vascular disorders favoring impaired cochlear perfusion. A number of inherited prothrombotic risk factors have been considered in the pathogenesis of vascular impairment and the possible role of genetic alterations has recently been suggested. We aimed to investigate the relationship between SHL and MTHFR 677 and 1298 gene polymorphisms. Methods: DNA genotyping was performed on peripheral blood leukocytes in 45 SHL patients and 135 controls. Results: Wild-type MTHFR (677CC/1298AA) was significantly more frequent in the controls (P = 0.01), and gene polymorphisms (677CT, 677TT, 1298AC, 1298CC, compound 677CT/1298AC) were significantly more frequent in the patients (P = 0.005; Ptrend = 0.001). Conclusion: These data suggest that MTHFR gene polymorphisms may be considered as risk factors for SHL and participate on vascular impairment related to this disorder. Further studies, based on large series of patients, are needed to definitely assess the role of this prothrombotic factor in the etiopathogenesis of SHL.
引用
收藏
页码:206 / 208
页数:3
相关论文
共 19 条
  • [11] Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease
    Lane, DA
    Grant, PJ
    [J]. BLOOD, 2000, 95 (05) : 1517 - 1532
  • [12] A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk
    Lievers, KJA
    Boers, GHJ
    Verhoef, P
    den Heijer, M
    Kluijtmans, LAJ
    van der Put, NMJ
    Trijbels, FJM
    Blom, HJ
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2001, 79 (09): : 522 - 528
  • [13] Folic acid and homocysteine in age-related disease
    Mattson, MP
    Kruman, II
    Duan, W
    [J]. AGEING RESEARCH REVIEWS, 2002, 1 (01) : 95 - 111
  • [14] Anti-endothelial autoantibodies in patients with sudden hearing loss
    Ottaviani, F
    Cadoni, G
    Marinelli, L
    Fetoni, AR
    De Santis, A
    Romito, A
    Vulpiani, P
    Manna, R
    [J]. LARYNGOSCOPE, 1999, 109 (07) : 1084 - 1087
  • [15] Patscheke JH, 2001, THROMB HAEMOSTASIS, V86, P1118
  • [16] Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss
    Rudack, C
    Langer, C
    Junker, R
    [J]. HEARING RESEARCH, 2004, 191 (1-2) : 41 - 48
  • [17] Sacchi E, 1997, THROMB HAEMOSTASIS, V78, P963
  • [18] Schweinfurth JM, 2000, AM J OTOL, V21, P636
  • [19] Zetterberg Henrik, 2004, Reprod Biol Endocrinol, V2, P7