A stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia

被引：4

作者：

Jaekel, Frank ^{[1
]}

Worm, Oliver ^{[1
]}

Lange, Sascha ^{[1
]}

Mertelsmann, Roland ^{[2
]}

机构：

[1] Psiori GmbH, Freiburg, Germany

[2] Univ Klinikum Freiburg, Innere Med 1, Freiburg, Germany

来源：

PLOS ONE | 2018年 / 13卷 / 10期

关键词：

SELF-RENEWAL; STEM-CELLS; CANCER; CLASSIFICATION; DISEASE;

D O I：

10.1371/journal.pone.0204393

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia.

引用

页数：25

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