IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

被引：810

作者：

Munn, David H. ^{[1
,2
]}

Mellor, Andrew L. ^{[3
]}

机构：

[1] Georgia Regents Univ, Med Coll Georgia, Ctr Canc, Augusta, GA 30904 USA

[2] Georgia Regents Univ, Med Coll Georgia, Dept Pediat, Augusta, GA 30904 USA

[3] Newcastle Univ, Sch Med, Inst Cellular Med, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 03期

关键词：

T-CELL RESPONSES; PLASMACYTOID DENDRITIC CELLS; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; ARYL-HYDROCARBON RECEPTOR; GRAFT-VERSUS-HOST; TRYPTOPHAN CATABOLISM; SUPPRESSOR-CELLS; I INTERFERON; IFN-GAMMA; IMMUNE-RESPONSES;

D O I：

10.1016/j.it.2016.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell activation, either spontaneous or due to immunotherapy. Here we review the current understanding of mechanisms by which IDO participates in the control of inflammation and in peripheral tolerance. Focusing on the tumor microenvironment, we examine the role of IDO in response to apoptotic cells and the impact of IDO on Treg cell function. We discuss how the counter regulatory and tolerogenic functions of IDO can be targeted for cancer immunotherapy and present an overview of the current clinical progress in this area.

引用

页码：193 / 207

页数：15

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