Novel Schiff bases-based thiophenes: Design, synthesis and biological evaluation

被引：4

作者：

Puthran, Divyaraj ^{[1
,2
]}

Poojary, Boja ^{[1
]}

Nayak, Soukhyarani G. ^{[1
]}

Purushotham, Nikil ^{[1
]}

Bhat, Manjunath ^{[3
]}

Hedge, Hemant ^{[4
]}

机构：

[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India

[2] Solara Act Pharma Sci Ltd, Proc & Dev Lab, New Mangalore, India

[3] Ark Gen Pharma Private Ltd, Res & Dev Lab, Bangalore, Karnataka, India

[4] Manipal Acad Higher Educ, Dept Chem, Manipal, India

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2020年 / 67卷 / 07期

关键词：

1-(3-fluoro-4-methoxyphenyl)ethanone; antimicrobial; Gewald synthesis; Schiff base; PYRAZOLE; ANTIBACTERIAL; ACID;

D O I：

10.1002/jccs.201900388

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-amino-5-(3-fluoro-4-methoxyphenyl)thiophene-3-carbonitrile derivatives have been synthesized from 1-(3-fluoro-4-methoxyphenyl)ethanone, malononitrile, mild base, and sulfur powder using the Gewald method through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of their elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectral data, and then synthesized compounds were screened for their in vitro antimicrobial activity. Among them, derivatives 3b (thiphene), 3f (pyrazole), and 3d (halogen) showed good activity and remaining derivatives exhibited moderate activity.

引用

页码：1278 / 1288

页数：11

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