Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis

被引：45

作者：

Lyles, John ^{[1
]}

Rothenberg, Marc ^{[2
]}

机构：

[1] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Dept Pediat,Div Gastroenterol Hepatol & Nutr, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat, Div Allergy & Immunol,Cincinnati Childrens Hosp M, 3333 Burnet Ave, Cincinnati, OH 45229 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2019年 / 60卷

关键词：

THYMIC STROMAL LYMPHOPOIETIN; VARIANTS; SUSCEPTIBILITY; ASSOCIATION; EXPRESSION; EOTAXIN-3; FEATURES; COSTS; LIFE; FOOD;

D O I：

10.1016/j.coi.2019.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The rise in incidence and prevalence of eosinophilic esophagitis (EoE) since the 1990s has prompted investigations into its pathogenesis, natural history, and management. Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants in CCL26, POSTN, and TSLP associate EoE with T helper type 2-mediated immunity. Early-life, infectious, and geographic factors have been implicated in promoting esophageal microbial dysbiosis and, subsequently, T helper type 2 immune responses. However, research into environmental factors and their interactions with genetic variants are not as developed as their genetic counterparts. Further research into the subgroups and epigenetics of EoE will likely promote further understanding.

引用

收藏

页码：46 / 53

页数：8

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