Fas Deficiency Exacerbates Cerulein-Induced Pancreatitis

被引：12

作者：

Jeyarajah, D. Rohan ^{[1
,2
]}

Kielar, M. ^{[2
]}

Gokaslan, S. T. ^{[3
]}

Lindberg, G. ^{[3
]}

Lu, C. Y. ^{[2
]}

机构：

[1] Univ Texas SW Med Sch, Dept Surg, Dallas, TX USA

[2] Univ Texas SW Med Sch, Dept Internal Med, Dallas, TX USA

[3] Univ Texas SW Med Sch, Dept Pathol, Dallas, TX USA

来源：

JOURNAL OF INVESTIGATIVE SURGERY | 2003年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

apoptosis; FAS; pancreatitis;

D O I：

10.1080/08941930390249865

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Acute pancreatitis results in many deaths each year. Our understanding of the pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis is Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greater than in the Fas-sufficient mouse. Histoloty graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This findings suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.

引用

页码：325 / 333

页数：9

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