Facile access to oxazolidin-2-imine, thiazolidin-2-imine and imidazolidin-2-imine derivatives bearing an exocyclic haloalkyliene via direct halocyclization between propargylamines, heterocumulenes and I2 (NBS)

被引：15
作者：
Huang, Shujian [1 ]
Shao, Yinlin [1 ]
Liu, Ruiting [1 ]
Zhou, Xigeng [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 24期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
Heterocycles; Metal-free; Iodocyclization; Propargylamines; CATALYZED CYCLOISOMERIZATIONS; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED IMIDAZOLES; ANTIMICROBIAL ACTIVITY; CYCLIC GUANIDINES; VINYL HALIDES; OXAZOLE; CYCLIZATION; INHIBITORS; ACID;
D O I：
10.1016/j.tet.2015.04.080
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, cheap, efficient, and metal-free method for one-step synthesis of a library of 1,3-diheteroatom five-membered heterocycles with exocyclic C=N and C=C double bonds was presented. The convenient reactions proceed via the direct three-component halocyclization of propargylamines, heterocumulenes and I-2 (NBS). (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4219 / 4226
页数：8
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