Facile access to oxazolidin-2-imine, thiazolidin-2-imine and imidazolidin-2-imine derivatives bearing an exocyclic haloalkyliene via direct halocyclization between propargylamines, heterocumulenes and I2 (NBS)

被引：15

作者：

Huang, Shujian ^{[1
]}

Shao, Yinlin ^{[1
]}

Liu, Ruiting ^{[1
]}

Zhou, Xigeng ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 24期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Heterocycles; Metal-free; Iodocyclization; Propargylamines; CATALYZED CYCLOISOMERIZATIONS; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED IMIDAZOLES; ANTIMICROBIAL ACTIVITY; CYCLIC GUANIDINES; VINYL HALIDES; OXAZOLE; CYCLIZATION; INHIBITORS; ACID;

D O I：

10.1016/j.tet.2015.04.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, cheap, efficient, and metal-free method for one-step synthesis of a library of 1,3-diheteroatom five-membered heterocycles with exocyclic C=N and C=C double bonds was presented. The convenient reactions proceed via the direct three-component halocyclization of propargylamines, heterocumulenes and I-2 (NBS). (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4219 / 4226

页数：8

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